Gene-environment interactions in the development of complex disease phenotypes
RG Ramos, K Olden - International journal of environmental research and …, 2008 - mdpi.com
The lack of knowledge about the earliest events in disease development is due to the multi-
factorial nature of disease risk. This information gap is the consequence of the lack of …
factorial nature of disease risk. This information gap is the consequence of the lack of …
Social ecology of children's vulnerability to environmental pollutants
B Weiss, DC Bellinger - Environmental health perspectives, 2006 - ehp.niehs.nih.gov
Background The outcomes of exposure to neurotoxic chemicals early in life depend on the
properties of both the chemical and the host's environment. When our questions focus on the …
properties of both the chemical and the host's environment. When our questions focus on the …
Roll over Weismann: extracellular vesicles in the transgenerational transmission of environmental effects
SA Eaton, N Jayasooriah, ME Buckland, DIK Martin… - …, 2015 - Taylor & Francis
The ability of environmental exposures to induce phenotypic change across multiple
generations of offspring has gathered an enormous amount of interest in recent years. There …
generations of offspring has gathered an enormous amount of interest in recent years. There …
[HTML][HTML] Present and future challenges for the investigation of transgenerational epigenetic inheritance
Epigenetic pathways are essential in different biological processes and in phenotype-
environment interactions in response to different stressors and they can induce phenotypic …
environment interactions in response to different stressors and they can induce phenotypic …
Early adversity and developmental outcomes: Interaction between genetics, epigenetics, and social experiences across the life span
FA Champagne - Perspectives on psychological science, 2010 - journals.sagepub.com
Longitudinal studies in humans demonstrate the association between prenatal and
postnatal experiences of adversity and long-term changes in neurodevelopment. These …
postnatal experiences of adversity and long-term changes in neurodevelopment. These …
Environmentally induced epigenetic transgenerational inheritance of phenotype and disease
C Guerrero-Bosagna, MK Skinner - Molecular and cellular endocrinology, 2012 - Elsevier
Environmental epigenetics has an important role in regulating phenotype formation or
disease etiology. The ability of environmental factors and exposures early in life to alter …
disease etiology. The ability of environmental factors and exposures early in life to alter …
Epigenetic influence of stress and the social environment
K Gudsnuk, FA Champagne - ILAR journal, 2012 - academic.oup.com
Animal models of early-life stress and variation in social experience across the lifespan have
contributed significantly to our understanding of the environmental regulation of the …
contributed significantly to our understanding of the environmental regulation of the …
Predicting later-life outcomes of early-life exposures
K Boekelheide, B Blumberg, RE Chapin… - Environmental …, 2012 - ehp.niehs.nih.gov
Background: In utero exposure of the fetus to a stressor can lead to disease in later life.
Epigenetic mechanisms are likely mediators of later-life expression of early-life events …
Epigenetic mechanisms are likely mediators of later-life expression of early-life events …
Environmental exposures and gene regulation in disease etiology
TM Edwards, JP Myers - Environmental health perspectives, 2007 - ehp.niehs.nih.gov
Objective Health or disease is shaped for all individuals by interactions between their genes
and environment. Exactly how the environment changes gene expression and how this can …
and environment. Exactly how the environment changes gene expression and how this can …
Locating gene–environment interaction: at the intersections of genetics and public health
S Shostak - Social Science & Medicine, 2003 - Elsevier
Over the past two decades, the applications of genetic and genomic technologies have
begun to transform research questions and practices within epidemiology and toxicology …
begun to transform research questions and practices within epidemiology and toxicology …