Gene‐environment interplay in common complex diseases: forging an integrative model—recommendations from an NIH workshop

EB Bookman, K McAllister, E Gillanders… - Genetic …, 2011 - Wiley Online Library
Although it is recognized that many common complex diseases are a result of multiple
genetic and environmental risk factors, studies of gene‐environment interaction remain a …

Child development, molecular genetics, and what to do with genes once they are found

R Plotnin, M Rutter - Child development, 1998 - Wiley Online Library
Genes associated with behavioral dimensions and disorders are beginning to be identified.
Although it is difficult and expensive to find genes associated with behavior, it is relatively …

Do intrauterine or genetic influences explain the foetal origins of chronic disease? A novel experimental method for disentangling effects

A Thapar, G Harold, F Rice, XJ Ge, J Boivin… - BMC Medical Research …, 2007 - Springer
Background There is much evidence to suggest that risk for common clinical disorders
begins in foetal life. Exposure to environmental risk factors however is often not random …

Developmental origins of health and disease: new insights

MA Hanson, PD Gluckman - Basic & clinical pharmacology & …, 2008 - Wiley Online Library
Epidemiological and animal studies show that small changes in the developmental
environment can induce phenotypic changes affecting an individual's responses to their …

Epigenetics across the human lifespan

RR Kanherkar, N Bhatia-Dey, AB Csoka - Frontiers in cell and …, 2014 - frontiersin.org
Epigenetics has the potential to explain various biological phenomena that have heretofore
defied complete explication. This review describes the various types of endogenous human …

Epigenetic programming—The important first 1000 days

A Linnér, M Almgren - Acta Paediatrica, 2020 - Wiley Online Library
The perinatal period is a time of fast physiological change, including epigenetic
programming. Adverse events may lead to epigenetic changes, with implications for health …

Lessons learned from past gene-environment interaction successes

BR Ritz, N Chatterjee, M Garcia-Closas… - American journal of …, 2017 - academic.oup.com
Genetic and environmental factors are both known to contribute to susceptibility to complex
diseases. Therefore, the study of gene-environment interaction (G× E) has been a focus of …

From the outside in: biological mechanisms linking social and environmental exposures to chronic disease and to health disparities

SP Bagby, D Martin, ST Chung… - American journal of …, 2019 - ajph.aphapublications.org
The ongoing epidemic of chronic diseases involves a spectrum of clinical entities now
understood to represent late manifestations of progressive metabolic dysfunction initiated in …

Transgenerational epigenetic effects from male exposure to endocrine-disrupting compounds: a systematic review on research in mammals

O Van Cauwenbergh, A Di Serafino, J Tytgat… - Clinical …, 2020 - Springer
Assessing long-term health effects from a potentially harmful environment is challenging.
Endocrine-disrupting compounds (EDCs) have become omnipresent in our environment …