Applications of positron emission tomography in the development of molecular targeted cancer therapeutics

B Solomon, GA McArthur, C Cullinane, JR Zalcberg… - BioDrugs, 2003 - Springer
For molecular targeted cancer therapies to fulfill their promise in cancer treatment,
innovative approaches are required to overcome significant obstacles that exist in the …

Positron emission tomography imaging of small animals in anticancer drug development

EO Aboagye - Molecular Imaging and Biology, 2005 - Springer
Positron emission tomography (PET) imaging of small animals enables researchers to
bridge the gap between in vitro science and in vivo human studies. The imaging paradigm …

Positron emission tomography (PET): expanding the horizons of oncology drug development

LA Hammond, L Denis, U Salman, P Jerabek… - Investigational new …, 2003 - Springer
Positron emission tomography (PET) allows three-dimensional quantitative determination of
the distribution of radioactivity permitting measurement of physiological, biochemical, and …

Molecular imaging of targeted therapies with positron emission tomography: the visualization of personalized cancer care

LH Mammatas, HMW Verheul, NH Hendrikse… - Cellular Oncology, 2015 - Springer
Introduction Molecular imaging has been defined as the visualization, characterization and
measurement of biological processes at the molecular and cellular level in humans and …

Clinical translation of molecular imaging agents used in PET studies of cancer

LM Kenny, EO Aboagye - Advances in cancer research, 2014 - Elsevier
Over recent years, there has been a rapid expansion in our knowledge of the factors that
regulate tumor growth; this has resulted in the identification of new therapeutic targets and …

Positron emission tomography: applications in drug discovery and drug development

J Wang, L Maurer - Current topics in medicinal chemistry, 2005 - ingentaconnect.com
Positron Emission Tomography (PET) is a sophisticated nuclear imaging modality that
affords researchers the ability to conduct both functional and molecular imaging on …

Pet oncological radiopharmaceuticals: Current status and perspectives

M Lin, RP Coll, AS Cohen, DK Georgiou, HC Manning - Molecules, 2022 - mdpi.com
Molecular imaging is the visual representation of biological processes that take place at the
cellular or molecular level in living organisms. To date, molecular imaging plays an …

Radiolabelled tracers and anticancer drugs for assessment of therapeutic efficacy using PET

F Brady, SK Luthra, GD Brown, S Osman… - Current …, 2001 - ingentaconnect.com
Positron Emission Tomography (PET) has the potential to improve efficacy of established
and novel cancer therapies and to assist more rapid and rational progression of promising …

Clinical molecular imaging with positron emission tomography

A Saleem, N Charnley, P Price - European Journal of Cancer, 2006 - Elsevier
Molecular imaging allows for the in vivo evaluation of targeted molecules and biological
processes in man. Positron emission tomography (PET) is a highly sensitive and quantitative …

Developing new molecular imaging probes for PET

K Serdons, A Verbruggen, GM Bormans - Methods, 2009 - Elsevier
Positron emission tomography (PET) is a fully translational molecular imaging technique that
requires specific probes radiolabelled with short-lived positron emitting radionuclides. This …