Hybrid Pathogenicity Island PAGI-5 Contributes to the Highly Virulent Phenotype of a Pseudomonas aeruginosa Isolate in Mammals

SE Battle, F Meyer, J Rello, VL Kung… - Journal of …, 2008 - Am Soc Microbiol
Most known virulence determinants of Pseudomonas aeruginosa are remarkably conserved
in this bacterium's core genome, yet individual strains differ significantly in virulence. One …

The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes

J He, RL Baldini, E Déziel, M Saucier… - Proceedings of the …, 2004 - National Acad Sciences
The ubiquitous bacterium Pseudomonas aeruginosa is the quintessential opportunistic
pathogen. Certain isolates infect a broad range of host organisms, from plants to humans …

Genomic islands of Pseudomonas aeruginosa

SE Battle, J Rello, AR Hauser - FEMS microbiology letters, 2009 - academic.oup.com
Key to Pseudomonas aeruginosa's ability to thrive in a diversity of niches is the presence of
numerous genomic islands that confer adaptive traits upon individual strains. We reasoned …

Pathogenicity Islands PAPI-1 and PAPI-2 Contribute Individually and Synergistically to the Virulence of Pseudomonas aeruginosa Strain PA14

EM Harrison, MEK Carter, S Luck, HY Ou… - Infection and …, 2010 - Am Soc Microbiol
Pseudomonas aeruginosa is a leading cause of hospital-acquired pneumonia and severe
chronic lung infections in cystic fibrosis patients. The reference strains PA14 and PAO1 have …

Extensive Genomic Plasticity in Pseudomonas aeruginosa Revealed by Identification and Distribution Studies of Novel Genes among Clinical Isolates

K Shen, S Sayeed, P Antalis, J Gladitz… - Infection and …, 2006 - Am Soc Microbiol
The distributed genome hypothesis (DGH) states that each strain within a bacterial species
receives a unique distribution of genes from a population-based supragenome that is many …

The Pseudomonas aeruginosa Pathogenicity Island PAPI-1 Is Transferred via a Novel Type IV Pilus

MQ Carter, J Chen, S Lory - Journal of bacteriology, 2010 - Am Soc Microbiol
Pseudomonas aeruginosa is a major cause of nosocomial infections, particularly in
immunocompromised patients or in individuals with cystic fibrosis. The notable ability of P …

Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial

DG Lee, JM Urbach, G Wu, NT Liberati, RL Feinbaum… - Genome biology, 2006 - Springer
Background Pseudomonas aeruginosa is a ubiquitous environmental bacterium and an
important opportunistic human pathogen. Generally, the acquisition of genes in the form of …

Identification of a Genomic Island Present in the Majority of Pathogenic Isolates of Pseudomonas aeruginosa

X Liang, XQT Pham, MV Olson, S Lory - Journal of bacteriology, 2001 - Am Soc Microbiol
Pseudomonas aeruginosa, a ubiquitous gram-negative bacterium, is capable of colonizing a
wide range of environmental niches and can also cause serious infections in humans. In …

Elucidating the molecular mechanisms of bacterial virulence using non‐mammalian hosts

S Mahajan‐Miklos, LG Rahme… - Molecular …, 2000 - Wiley Online Library
Several strains of the human opportunistic pathogen Pseudomonas aeruginosa infect
plants, nematodes and insects. Our laboratory has developed a multihost pathogenesis …

Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa

MC Wolfgang, BR Kulasekara… - Proceedings of the …, 2003 - National Acad Sciences
Pseudomonas aeruginosa is a ubiquitous environmental bacterium capable of causing a
variety of life-threatening human infections. The genetic basis for preferential infection of …