Purpose Curcumin, a plant-derived natural polyphenol, could be a promising anti-cancer
drug and shows synergic effects with cytotoxic agents. We evaluated the safety and …

Curcumin has a potent antiproliferative activity and can also potentiate the antitumor effect of
gemcitabine. This study was undertaken to evaluate the activity and feasibility of …

Purpose: Pancreatic cancer is almost always lethal, and the only US Food and Drug
Administration–approved therapies for it, gemcitabine and erlotinib, produce objective …

A large body of biomedical evidence indicates that activation of Nrf2 by curcumin increases
the nucleophilic tone and damps inflammation cumulatively supporting the malignant …

A number of preclinical studies have demonstrated anticancer effects for curcumin in various
types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone …

Pancreatic cancer (PC) is one of the deadliest cancers worldwide. Surgical resection
remains the only curative therapeutic treatment for this disease, although only the minority of …

Curcumin induces cancer cell growth arrest and apoptosis in vitro, but its poor bioavailability
in vivo limits its antitumor efficacy. We have previously evaluated the bioavailability of novel …

Dear Editor, Curcumin is a yellow–orange pigment obtained from the plant Curcuma longa.
The powdered rhizome of this plant, called turmeric, is a common ingredient in curry …

Background and aim: Gemcitabine, the first-line agent in pancreatic adenocarcinoma, has
shown limited clinical benefit. Cyclooxygenase-2 (COX-2) represent one of the most …

Pancreatic cancer (PaCa) is a major health concern due to its aggressiveness and early
metastasis. Current treatments for PaCa are limited by development of resistance against …