Point mutations that trigger ligand-independent proteolysis of the Notch1 ectodomain occur
frequently in human T-cell acute lymphoblastic leukemia (T-ALL) but are rare in murine T …

Although prognosis has improved for children with T-cell acute lymphoblastic leukemia (T-
ALL), 20% to 30% of patients undergo induction failure (IF) or relapse. Leukemia-initiating …

Notch receptors participate in a conserved signaling pathway that controls the development
of diverse tissues and cell types, including lymphoid cells. Signaling is normally initiated …

Notch signaling plays a critical role in T‐cell differentiation and leukemogenesis. We
previously demonstrated that, while pre‐TCR is required for thymocytes proliferation and …

Notch signaling is a key developmental pathway that is subject to frequent genetic and
epigenetic perturbations in many different human tumors. Here we investigate whether long …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor resulting
from the malignant transformation of immature T-cell progenitors. Originally associated with …

Although Notch1 and Notch2 are closely related paralogs and function through the same
canonical signaling pathway, they contribute to different outcomes in some cell and disease …

The Notch signaling pathway is a regulator of self-renewal and differentiation in several
tissues and cell types. Notch is a binary cell-fate determinant, and its hyperactivation has …

Precise control of the timing and magnitude of Notch signaling is essential for the normal
development of many tissues, but the feedback loops that regulate Notch are poorly …

T-cell acute lymphoblastic leukaemia (T-ALL) is a blood malignancy afflicting mainly
children and adolescents. T-ALL patients present at diagnosis with increased white cell …