Understanding the pathways that regulate the human T-cell acute lymphoblastic leukemia (T-
ALL) initiating cells (T-LiC) activity has been hampered by the lack of biologic assays in …

Notch1 signaling is required for T cell development. We have previously demonstrated that
expression of a dominant active Notch1 (ICN1) transgene in hematopoietic stem cells …

Ontogenesis of T cells in the thymus is a complex process whose molecular control is poorly
understood. The present study investigated microRNAs involved in human thymocyte …

Activated CD8+ T cells choose between terminal effector cell (TEC) or memory precursor
cell (MPC) fates. We found that the signaling receptor Notch controls this' choice'. Notch …

Postnatal bone marrow houses mesenchymal progenitor cells that are osteoblast
precursors. These cells have established therapeutic potential, but they are difficult to …

Activating mutations in NOTCH1 are common in T cell acute lymphoblastic leukemia (T-
ALL). Here we identify glutaminolysis as a critical pathway for leukemia cell growth …

NOTCH1 is activated by mutation in more than 50% of human T-cell acute lymphoblastic
leukemias (T-ALLs) and inhibition of Notch signaling causes cell-cycle/growth arrest …

The Notch signaling pathway regulates many aspects of embryonic development, as well as
differentiation processes and tissue homeostasis in multiple adult organ systems …