Effects of losartan and captopril on mortality and morbidity in high-risk patients after acute myocardial infarction: the OPTIMAAL randomised trial

K Dickstein, J Kjekshus - The Lancet, 2002 - thelancet.com
Background ACE inhibitors attenuate the detrimental effects of angiotensin II, and improve
survival and reduce morbidity in patients with acute myocardial infarction and evidence of …

Comparison of the effects of losartan and captopril on mortality in patients after acute myocardial infarction: the OPTIMAAL trial design

K Dickstein, J Kjekshus… - The American journal of …, 1999 - Elsevier
Patients with acute myocardial infarction and evidence of heart failure or left ventricular
dysfunction during the acute phase have an excessive mortality risk. Therapy with …

Angiotensin II and trials of cardiovascular outcomes

P Sleight - The American journal of cardiology, 2002 - Elsevier
Proven cardiovascular benefit from angiotensin-converting enzyme (ACE) inhibition is a
cornerstone of evidence-based medicine. The first study to show dramatic benefits from ACE …

Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both

MA Pfeffer, JJV McMurray, EJ Velazquez… - … England Journal of …, 2003 - Mass Medical Soc
Background Angiotensin-converting–enzyme (ACE) inhibitors such as captopril reduce
mortality and cardiovascular morbidity among patients with myocardial infarction …

Which inhibitor of the renin–angiotensin system should be used in chronic heart failure and acute myocardial infarction?

JJV McMurray, MA Pfeffer, K Swedberg, VJ Dzau - Circulation, 2004 - Am Heart Assoc
puted placebo analysis). 21 In this analysis, losartan 50 mg once daily could not be shown
to be better than placebo. Concern that the dose of losartan was too low in this trial (and in …

[HTML][HTML] Angiotensin receptor–neprilysin inhibition in acute myocardial infarction

MA Pfeffer, B Claggett, EF Lewis… - … England Journal of …, 2021 - Mass Medical Soc
Background In patients with symptomatic heart failure, sacubitril–valsartan has been found
to reduce the risk of hospitalization and death from cardiovascular causes more effectively …

Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial—the Losartan Heart Failure Survival Study ELITE II

B Pitt, PA Poole-Wilson, R Segal, FA Martinez… - The Lancet, 2000 - thelancet.com
Background The ELITE study showed an association between the angiotensin II antagonist
losartan and an unexpected survival benefit in elderly heart-failure patients, compared with …

The effect of valsartan, captopril, or both on atherosclerotic events after acute myocardial infarction: an analysis of the Valsartan in Acute Myocardial Infarction Trial …

J McMurray, S Solomon, K Pieper, S Reed… - Journal of the American …, 2006 - jacc.org
Objectives: We attempted to compare the effect of an angiotensin-converting enzyme (ACE)
inhibitor and angiotensin receptor blocker (ARB) on atherosclerotic events. Background …

Valsartan in acute myocardial infarction trial (VALIANT): rationale and design

MA Pfeffer, J McMurray, A Leizorovicz, AP Maggioni… - American heart …, 2000 - Elsevier
Background Survivors of acute myocardial infarction (MI) complicated by heart failure and/or
resulting in left ventricular dysfunction are at heightened risk for subsequent death and …

Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction: results of the Cooperative New Scandinavian Enalapril Survival …

K Swedberg, P Held, J Kjekshus… - … England Journal of …, 1992 - Mass Medical Soc
Background. Long-term administration of angiotensin-converting—enzyme (ACE) inhibitors
has been shown to improve survival in patients with symptomatic left ventricular failure and …