Effect of enalapril on 12-year survival and life expectancy in patients with left ventricular systolic dysfunction: a follow-up study

P Jong, S Yusuf, MF Rousseau, SA Ahn, SI Bangdiwala - The Lancet, 2003 - thelancet.com
Background In the studies of left ventricular dysfunction (SOLVD), enalapril reduced
mortality in patients with symptomatic but not asymptomatic left ventricular systolic …

Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion

B Zhu, Y Sun, RE Sievers, AEM Browne… - Journal of the American …, 2000 - jacc.org
OBJECTIVES We sought to assess the comparative effects of pretreatment with captopril
and losartan on myocardial infarct size and arrhythmias in a rat model of ischemia …

Cardiovascular morbidity and mortality in patients with diabetes in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial …

LH Lindholm, H Ibsen, B Dahlöf, RB Devereux… - The Lancet, 2002 - thelancet.com
Background The most suitable antihypertensive drug to reduce the risk of cardiovascular
disease in patients with hypertension and diabetes is unclear. In prespecified analyses, we …

Atenolol use and clinical outcomes after thrombolysis for acute myocardial infarction: the GUSTO-I experience

M Pfisterer, JL Cox, CB Granger, SJ Brener… - Journal of the American …, 1998 - jacc.org
Objectives. We assessed the use and effects of acute intravenous and later oral atenolol
treatment in a prospectively planned post hoc analysis of the GUSTO-I dataset. Background …

Omapatrilat-the story of Overture and Octave

AJS Coats - International journal of cardiology, 2002 - Elsevier
At the American College of Cardiology in March two major trials were presented. The
publicity surrounding the two could not have been more different. The LIFE demonstrated …

Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial

S Julius, SE Kjeldsen, M Weber, HR Brunner, S Ekman… - The Lancet, 2004 - thelancet.com
Summary Background The Valsartan Antihypertensive Long-term Use Evaluation (VALUE)
trial was designed to test the hypothesis that for the same blood-pressure control, valsartan …

Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme

MA Pfeffer, K Swedberg, CB Granger, P Held… - The Lancet, 2003 - thelancet.com
Background Patients with chronic heart failure (CHF) are at high risk of cardiovascular death
and recurrent hospital admissions. We aimed to find out whether the use of an angiotensin …