Diabetic nephropathy is the major cause of end-stage renal disease worldwide. Although
the renin–angiotensin system has been implicated in the pathogenesis of diabetic …

Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac
remodeling in chronic renal failure. Background Tissue kallikrein cleaves kininogen …

Tissue kallikrein (TK), the major kinin-forming enzyme, is synthesized in several organs,
including the kidney and arteries. A loss-of-function polymorphism of the human TK gene …

Assembly and activation of the plasma KKS on endothelial cells. Plasma PK circulates in
complex with HK. The HK• PK complex binds to a multiprotein receptor complex that consists …

Kallikreins are a subgroup of serine proteases with diverse physiological functions. The
human kallikrein gene family has now been fully characterized and includes 15 members …

Angiogenesis is the sprouting of new capillary blood vessels from pre-existing ones. The
kinin family of vasoactive peptides, formed by the serine protease tissue kallikrein from its …

The renin-angiotensin system (RAS) and the kallikrein-kinin system (KKS) are important in
the aetiology of hypertension and the pathogenesis of cardiac and renal damage associated …

The formation of new blood vessels is viewed completely differently by cardiologists than by
oncologists and ophthalmologists. Whereas the former try to stimulate this process, the latter …

To clarify the role of the kallikrein-kinin system in cardiovascular homeostasis, the systemic
and regional hemodynamics of kinin B2 receptor–deficient (B2−/−) and tissue kallikrein …

The renin-angiotensin (RAS) and kallikrein-kinin (KKS) systems play a key role in multiple
physiological and pathophysiological conditions, including growth and development …