Admixed populations improve power for variant discovery and portability in genome-wide association studies
Genome-wide association studies (GWAS) are primarily conducted in single-ancestry
settings. The low transferability of results has limited our understanding of human genetic …
settings. The low transferability of results has limited our understanding of human genetic …
The construction of multi-ethnic polygenic risk score using transfer learning
As most existing genome-wide association studies (GWAS) were conducted in European
ancestry cohorts and as the existing PRS models have limited transferability across ancestry …
ancestry cohorts and as the existing PRS models have limited transferability across ancestry …
Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations
Polygenic scores (PGS) have been widely used to predict disease risk using variants
identified from genome-wide association studies (GWAS). To date, most GWAS have been …
identified from genome-wide association studies (GWAS). To date, most GWAS have been …
[HTML][HTML] Comparing within-and between-family polygenic score prediction
Polygenic scores are a popular tool for prediction of complex traits. However, prediction
estimates in samples of unrelated participants can include effects of population stratification …
estimates in samples of unrelated participants can include effects of population stratification …
Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning
Methods of estimating polygenic scores (PGSs) from genome-wide association studies are
increasingly utilized. However, independent method evaluation is lacking, and method …
increasingly utilized. However, independent method evaluation is lacking, and method …
Novel methods for multi-ancestry polygenic prediction and their evaluations in 5.1 million individuals of diverse ancestry
Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …
suboptimal performance in non-European ancestry populations raises questions about their …
Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores
Polygenic risk scores suffer reduced accuracy in non-European populations, exacerbating
health disparities. We propose PolyPred, a method that improves cross-population …
health disparities. We propose PolyPred, a method that improves cross-population …
Genetic nature or genetic nurture? Quantifying bias in analyses using polygenic scores
S Trejo, BW Domingue - BioRxiv, 2019 - biorxiv.org
Abstract Summary statistics from a genome-wide association study (GWAS) can be used to
generate a polygenic score (PGS). For complex, behavioral traits, the correlation between …
generate a polygenic score (PGS). For complex, behavioral traits, the correlation between …
Low and differential polygenic score generalizability among African populations due largely to genetic diversity
African populations are vastly underrepresented in genetic studies but have the most
genetic variation and face wide-ranging environmental exposures globally. Because …
genetic variation and face wide-ranging environmental exposures globally. Because …
Causal effects on complex traits are similar across segments of different continental ancestries within admixed individuals
Individuals of admixed ancestries (eg, African Americans) inherit a mosaic of ancestry
segments (local ancestry) originating from multiple continental ancestral populations. Their …
segments (local ancestry) originating from multiple continental ancestral populations. Their …