Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue
G Rajkowska, CA Stockmeier - Current drug targets, 2013 - ingentaconnect.com
The present paper reviews astrocyte pathology in major depressive disorder (MDD) and
proposes that reductions in astrocytes and related markers are key features in the pathology …
proposes that reductions in astrocytes and related markers are key features in the pathology …
An astroglial basis of major depressive disorder? An overview
Q Wang, W Jie, JH Liu, JM Yang, TM Gao - Glia, 2017 - Wiley Online Library
Depression is a chronic, recurring, and serious mood disorder that afflicts up to 20% of the
global population. The monoamine hypothesis has dominated our understanding of the …
global population. The monoamine hypothesis has dominated our understanding of the …
Antidepressants act directly on astrocytes: evidences and functional consequences
B Czéh, B Di Benedetto - European Neuropsychopharmacology, 2013 - Elsevier
Post-mortem histopathological studies report on reduced glial cell numbers in various
frontolimbic areas of depressed patients implying that glial loss together with abnormal …
frontolimbic areas of depressed patients implying that glial loss together with abnormal …
From pathophysiology to novel antidepressant drugs: glial contributions to the pathology and treatment of mood disorders
G Sanacora, M Banasr - Biological Psychiatry, 2013 - Elsevier
Several structural and cellular changes, including marked glial anomalies, have been
observed in association with major depressive disorder. Here we review these cellular …
observed in association with major depressive disorder. Here we review these cellular …
Gliogenesis and glial pathology in depression
G Rajkowska, JJ Miguel-Hidalgo - CNS & Neurological …, 2007 - ingentaconnect.com
Recent research has changed the perception of glia from being no more than silent
supportive cells of neurons to being dynamic partners participating in brain metabolism and …
supportive cells of neurons to being dynamic partners participating in brain metabolism and …
Implication of cerebral astrocytes in major depression: a review of fine neuroanatomical evidence in humans
LA O'Leary, N Mechawar - Glia, 2021 - Wiley Online Library
Postmortem investigations have implicated astrocytes in many neurological and psychiatric
conditions. Multiple brain regions from individuals with major depressive disorder (MDD) …
conditions. Multiple brain regions from individuals with major depressive disorder (MDD) …
Astroglial correlates of neuropsychiatric disease: From astrocytopathy to astrogliosis
Complex roles for astrocytes in health and disease continue to emerge, highlighting this
class of cells as integral to function and dysfunction of the nervous system. In particular …
class of cells as integral to function and dysfunction of the nervous system. In particular …
[HTML][HTML] Astrocytes in depression and Alzheimer's disease
Y Liao, Q Xing, Q Li, J Zhang, R Pan, Z Yuan - Frontiers of medicine, 2021 - Springer
Astrocytes are an abundant subgroup of cells in the central nervous system (CNS) that play
a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In …
a critical role in controlling neuronal circuits involved in emotion, learning, and memory. In …
Density of GFAP-immunoreactive astrocytes is decreased in left hippocampi in major depressive disorder
JA Cobb, K O'Neill, J Milner, GJ Mahajan, TJ Lawrence… - Neuroscience, 2016 - Elsevier
Neuroimaging and postmortem studies of subjects with major depressive disorder (MDD)
reveal smaller hippocampal volume with lengthening duration of illness. Pathology in …
reveal smaller hippocampal volume with lengthening duration of illness. Pathology in …
Effects of monoamines and antidepressants on astrocyte physiology: implications for monoamine hypothesis of depression
SV Marathe, PL D'almeida, G Virmani… - Journal of …, 2018 - journals.sagepub.com
Major depressive disorder (MDD) is one of the most common neuropsychiatric disorders
affecting over one-fifth of the population worldwide. Owing to our limited understanding of …
affecting over one-fifth of the population worldwide. Owing to our limited understanding of …