Metastatic or recurrent cervical cancer has limited treatment options and a high rate of
mortality. Although anti-vascular endothelial growth factor drugs have shown great promise …

Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2
(TIE2), the receptor for angiopoietins, has been found highly expressed in cervical cancer …

Angiopoietins have been increasingly implicated to play important roles in blood vessel
formation, remodeling, maturation, and maintenance. However, their roles in tumor …

Objectives. Lymph node metastasis (LNM) is an important determinant of prognosis in
patients with cervical cancer. Members of the angiopoietin family have been demonstrated …

Angiopoietin/tyrosine protein kinase receptor Tie-2 signaling in endothelial cells plays an
essential role in angiogenesis and wound healing. Angiopoietin-1 (Ang-1) is crucial for …

Objectives Angiopoietins have been found to play essential roles in tumor angiogenesis.
The present study was aimed at investigating the diagnostic and prognostic values of serum …

Purpose of investigation: Angiogenesis is important in the promotion and progression of
malignancy. The formation of new blood vessels is coordinated by many factors …

Abstract Purpose: Angiopoietin-1 (Ang1) plays a key role in maintaining stable vasculature,
whereas in a tumor Ang2 antagonizes Ang1's function and promotes the initiation of the …

Angiopoietin (Ang)-1 and-2, and mouse Ang-3/human Ang-4 are ligands of the receptor
tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Tie) …

Purpose: The role of angiopoietins (ANGs) in cancer progression is a new field of research.
We examined the patterns of expression of ANGs in human renal cancer tissues (n= 12) and …