Elevated progesterone receptor membrane component 1/sigma‐2 receptor levels in lung tumors and plasma from lung cancer patients
SUR Mir, ISA Ahmed, S Arnold… - International Journal of …, 2012 - Wiley Online Library
Cancer is one of the leading causes of death, and there is an urgent need for new
biomarkers and therapeutic targets. The progesterone receptor membrane component 1 …
biomarkers and therapeutic targets. The progesterone receptor membrane component 1 …
[HTML][HTML] PGRMC1 elevation in multiple cancers and essential role in stem cell survival
KK Hampton, R Stewart, D Napier… - Advances in lung …, 2015 - ncbi.nlm.nih.gov
Cancer is one of the leading causes of death in America, and there is an urgent need for
new therapeutic approaches. The progesterone receptor membrane component 1 …
new therapeutic approaches. The progesterone receptor membrane component 1 …
Progesterone receptor membrane component 1 (Pgrmc1): a heme-1 domain protein that promotes tumorigenesis and is inhibited by a small molecule
IS Ahmed, HJ Rohe, KE Twist, MN Mattingly… - … of Pharmacology and …, 2010 - ASPET
Tumorigenesis requires the concerted action of multiple pathways, including pathways that
stimulate proliferation and increase metabolism. Progesterone receptor membrane …
stimulate proliferation and increase metabolism. Progesterone receptor membrane …
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding
HJ Rohe, IS Ahmed, KE Twist, RJ Craven - Pharmacology & therapeutics, 2009 - Elsevier
Hormone signaling is important in a number of disease states, and hormone receptors are
effective therapeutic targets. PGRMC1 (progesterone receptor membrane component 1) is a …
effective therapeutic targets. PGRMC1 (progesterone receptor membrane component 1) is a …
Identification of PGRMC1 as a Candidate Oncogene for Head and Neck Cancers and Its Involvement in Metabolic Activities
Y Zhao, X Ruan - Frontiers in Bioengineering and Biotechnology, 2020 - frontiersin.org
Progesterone Receptor Membrane Component 1 (PGRMC1/Sigma-2 receptor) is located on
chromosome Xq21 and encodes a haem-containing protein that interacts with epidermal …
chromosome Xq21 and encodes a haem-containing protein that interacts with epidermal …
Sigma-2 receptor and progesterone receptor membrane component 1 (PGRMC1) are two different proteins: Proofs by fluorescent labeling and binding of sigma-2 …
ML Pati, D Groza, C Riganti, J Kopecka, M Niso… - Pharmacological …, 2017 - Elsevier
A controversial relationship between sigma-2 and progesterone receptor membrane
component 1 (PGRMC1) proteins, both representing promising targets for the therapy and …
component 1 (PGRMC1) proteins, both representing promising targets for the therapy and …
Increased expression of progesterone receptor membrane component 1 is associated with aggressive phenotype and poor prognosis in ER-positive and negative …
X Ruan, Y Zhang, AO Mueck, M Willibald, H Seeger… - Menopause, 2017 - journals.lww.com
Objective: Expression of progesterone receptor membrane component 1 (PGRMC1) has
been shown to be higher in breast cancer than normal tissue. We have previously shown …
been shown to be higher in breast cancer than normal tissue. We have previously shown …
Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling
Background Increased expression of the progesterone receptor membrane component 1
(PGRMC1) has been linked to multiple cancers, including breast cancer. Despite being a …
(PGRMC1) has been linked to multiple cancers, including breast cancer. Despite being a …
Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors
NC Clark, AM Friel, CA Pru, L Zhang… - Cancer biology & …, 2016 - Taylor & Francis
Triple negative breast cancers (TNBCs) are highly aggressive and grow in response to sex
steroid hormones despite lacking expression of the classical estrogen (E2) and …
steroid hormones despite lacking expression of the classical estrogen (E2) and …
Absence of progesterone receptor membrane component 1 reduces migration and metastasis of breast cancer
Background Progesterone receptor membrane component 1 (Pgrmc1) is a non-classical
progesterone receptor associated with the development of the mammary gland and …
progesterone receptor associated with the development of the mammary gland and …