Multiple sclerosis (MS) is a multifocal and progressive inflammatory disease of the central
nervous system (CNS). However, the compartmentalized pathology of the disease affecting …

The role of microglia and monocyte-derived macrophages in experimental autoimmune
encephalomyelitis pathogenesis has been controversial. To gain insight into their respective …

Microglia are tissue-resident macrophages of the CNS that orchestrate local immune
responses and contribute to several neurological and psychiatric diseases. Little is known …

Background Microglia are innate immune cells of the brain that perform phagocytic and
inflammatory functions in disease conditions. Transcriptomic studies of acutely-isolated …

Microglia are resident immune cells that play multiple roles in central nervous system (CNS)
development and disease. Although the classical concept of microglia/macrophage …

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …

Brain macrophage populations include parenchymal microglia, border-associated
macrophages, and recruited monocyte-derived cells; together, they control brain …

Microglia are increasingly recognized for their major contributions during brain development
and neurodegenerative disease. It is currently unknown whether these functions are carried …

Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …

In recent years, many paradigms concerning central nervous system (CNS) immunology
have been challenged and shifted, including the discovery of CNS-draining lymphatic …