Entry of SARS-CoV-2 into the central nervous system (CNS) activates microglia, triggering
chronic neuroinflammation and possibly neurodegeneration. The complex transcriptome of …

Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …

Background A key feature of the inflammatory response after cerebral ischemia is the brain
infiltration of blood monocytes. There are two main monocyte subsets in the mouse blood …

Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …

Maintenance of mammalian tissue homeostasis and function requires coordinated actions of
multiple cellular and molecular networks. This complexity is reflected in the immune system …

Monocyte-derived and tissue-resident macrophages are ontogenetically distinct
components of the innate immune system. Assessment of their respective functions in …

INTRODUCTION Resident tissue macrophages (RTMs) are a heterogeneous population of
immune cells occupying multiple tissue niches and exhibiting microenvironment-specific …

INTRODUCTION The meninges are a three-layer membrane that covers the central nervous
system (CNS): The outermost layer, the dura mater, is attached onto the skull periosteum; …

Whether monocytes contribute to the brain microglial pool in development or after brain
injury remains contentious. To address this issue, we generated CCR2-CreER mice to track …

Peripheral central nervous system (CNS)–infiltrating lymphocytes are a hallmark of
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …