In search for strategies aimed at preventing oxidative threat to female fertility, a possible role
of sirtuins has emerged. Sirtuins (silent information regulator 2 (Sir2) proteins), NAD+ …

Abstract BACKGROUND Sirtuins (SIRT1-7) are a family of NAD+-dependent deacetylases
that catalyze post-translational modifications of proteins. Together, they respond to …

Mitochondria act as hubs of numerous metabolic pathways. Mitochondrial dysfunctions
contribute to altering the redox balance and predispose to aging and metabolic alterations …

Silent information Regulators (SIRT1) gene stimulates antioxidants' expression, repairs cells
damaged by oxidative stress (OS), and prevents the cells' dysfunction. In particular, the role …

The NAD+‐dependent sirtuin deacetylase, Sirt1, regulates key transcription factors strongly
implicated in ageing and lifespan. Due to potential confounding effects secondary to loss of …

Reproduction is the way to immortality for an individual, and it is essential to the continuation
of the species. Sirtuins are involved in cellular homeostasis, energy metabolism, apoptosis …

Objective: To establish an oxidative stress-induced model of premature ovarian insufficiency
(POI) and to explore the effect of SIRT1 and mitochondrial oxidative phosphorylation on the …

SIRT3 is a member of the sirtuin family and has recently emerged as a vital molecule in
controlling the generation of reactive oxygen species (ROS) in oocytes. Appropriate levels of …

Women with reduced ovarian reserve or advanced maternal age have an altered metabolic
follicular microenvironment. As sirtuin 5 (SIRT5) senses cellular metabolic state and post …

The present short review demonstrates the involvement of sirtuins (SIRTs) in the control of
ovarian functions at various regulatory levels. External and endocrine factors can affect …