Osteoclasts are large multinucleated bone-resorbing cells formed by the fusion of monocyte/
macrophage-derived precursors that are thought to undergo apoptosis once resorption is …

Osteoclasts are bone resorbing, multinucleate cells that differentiate from mononuclear
macrophage/monocyte-lineage hematopoietic precursor cells. Although previous studies …

Osteoclasts are multinucleated, bone-resorbing cells formed via fusion of monocyte
progenitors, a process triggered by prolonged stimulation with RANKL, the osteoclast master …

Bone remodeling is precisely coordinated by bone resorption and formation. Apoptotic
osteoclasts generate large amounts of apoptotic bodies (ABs) marking the end of the bone …

Osteoclasts (OCs) are the cells uniquely responsible for dissolving both the organic and
inorganic components of bone during bone development and remodeling throughout life …

Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb
large quantities of bone. Therefore, they are frequently the target of therapeutic interventions …

It is important to understand the molecular mechanisms regulating osteoclast formation, as
excess activation of osteoclasts is associated with various osteopenic disorders. Receptor …

Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells
under different environmental stimuli. Bone-resorbing osteoclasts are derived from the …

In bone remodeling, after a lifespan of∼ 2 weeks, osteoclasts undergo apoptosis in each
bone turnover cycle, resulting in generation of a large number of apoptotic bodies (ABs) …

Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive
production or activation of osteoclasts leads to skeletal pathologies that affect a significant …