[HTML][HTML] Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): a single-centre, parallel-arm …

JZ Qu, A Mueller, TB McKay, MB Westover… - …, 2023 - thelancet.com
Background The delirium-sparing effect of nighttime dexmedetomidine has not been studied
after surgery. We hypothesised that a nighttime dose of dexmedetomidine would reduce the …

Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial

X Su, ZT Meng, XH Wu, F Cui, HL Li, DX Wang, X Zhu… - The Lancet, 2016 - thelancet.com
Background Delirium is a postoperative complication that occurs frequently in patients older
than 65 years, and presages adverse outcomes. We investigated whether prophylactic low …

[HTML][HTML] Impact of dexmedetomidine on the incidence of delirium in elderly patients after cardiac surgery: a randomized controlled trial

X Li, J Yang, XL Nie, Y Zhang, XY Li, LH Li, DX Wang… - PloS one, 2017 - journals.plos.org
Background Delirium is a frequent complication after cardiac surgery and its occurrence is
associated with poor outcomes. The purpose of this study was to investigate the impact of …

Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non-cardiac surgery

CJ Li, BJ Wang, DL Mu, J Hu, C Guo… - Journal of British …, 2020 - academic.oup.com
Background Delirium is common in elderly patients after surgery and is associated with poor
outcomes. This study aimed to investigate the impact of intraoperative dexmedetomidine on …

Perioperative dexmedetomidine reduces delirium after cardiac surgery: a meta-analysis of randomized controlled trials

M Wu, Y Liang, Z Dai, S Wang - Journal of clinical anesthesia, 2018 - Elsevier
Study objective To evaluate the efficiency of dexmedetomidine on the incidence of delirium
in patients after cardiac surgery. Design Meta-analysis of randomized controlled trials …

Perioperative dexmedetomidine supplement decreases delirium incidence after adult cardiac surgery: a randomized, double-blind, controlled study

VV Likhvantsev, G Landoni, OA Grebenchikov… - Journal of cardiothoracic …, 2021 - Elsevier
Objective Conflicting data exist on the effect of dexmedetomidine on delirium. For the
present study, a randomized trial was performed to investigate the effect of perioperative …

The effect of peri‐operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non‐cardiac surgical patients: a randomised, double‐blind …

J Van Norden, CD Spies, F Borchers, M Mertens… - …, 2021 - Wiley Online Library
Delirium occurs commonly following major non‐cardiac and cardiac surgery and is
associated with: postoperative mortality; postoperative neurocognitive dysfunction; …

Intraoperative infusion of dexmedetomidine for prevention of postoperative delirium and cognitive dysfunction in elderly patients undergoing major elective noncardiac …

S Deiner, X Luo, HM Lin, DI Sessler, L Saager… - JAMA …, 2017 - jamanetwork.com
Importance Postoperative delirium occurs in 10% to 60% of elderly patients having major
surgery and is associated with longer hospital stays, increased hospital costs, and 1-year …

[HTML][HTML] Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised …

X Duan, M Coburn, R Rossaint, RD Sanders… - British journal of …, 2018 - Elsevier
Background The influence of dexmedetomidine on postoperative delirium (POD) in adult
surgical patients remains controversial. We aimed to analyse whether dexmedetomidine use …

[HTML][HTML] Dexmedetomidine for the prevention of postoperative delirium in elderly patients undergoing noncardiac surgery: a meta-analysis of randomized controlled …

H Zeng, Z Li, J He, W Fu - PLoS One, 2019 - journals.plos.org
Background Postoperative delirium (POD) among the elderly population that undergoes
noncardiac surgery is significantly associated with adverse clinical outcomes. We conducted …