[HTML][HTML] Inducing iPSCs to escape the dish

B Barrilleaux, PS Knoepfler - Cell Stem Cell, 2011 - cell.com
Induced pluripotent stem cells (iPSCs) hold great promise for autologous cell therapies, but
significant roadblocks remain to translating iPSCs to the bedside. For example, concerns …

[HTML][HTML] Molecular obstacles to clinical translation of iPSCs

N Tapia, HR Schöler - Cell stem cell, 2016 - cell.com
The ability to reprogram somatic cells into induced pluripotent stem cells (iPSCs) using
defined factors provides new tools for biomedical research. However, some iPSC clones …

Induced pluripotent stem cells: The dragon awakens

W Han, Y Zhao, X Fu - BioScience, 2010 - academic.oup.com
Induced pluripotent stem cells (iPSCs) can be derived from many mouse and human
somatic cell types by forced expression of a small number of defined reprogramming factors …

Overcoming barriers to the clinical utilization of iPSCs: reprogramming efficiency, safety and quality

S Cao, K Loh, Y Pei, W Zhang, J Han - Protein & cell, 2012 - Springer
Differentiated cells can be reprogrammed into pluripotent stem cells, known as “induced
pluripotent stem cells”(iPSCs), through the overexpression of defined transcription factors …

Progress and promise towards safe induced pluripotent stem cells for therapy

A Seifinejad, M Tabebordbar, H Baharvand… - Stem Cell Reviews and …, 2010 - Springer
The recent generation of induced pluripotent stem cells (iPSCs) from somatic cells provides
an invaluable resource for drug or toxicology screening, medical research, and patient …

[HTML][HTML] Potential of induced pluripotent stem cells for use in gene therapy: History, molecular bases, and medical perspectives

A Fus-Kujawa, B Mendrek, A Trybus, K Bajdak-Rusinek… - Biomolecules, 2021 - mdpi.com
Induced pluripotent stem cells (iPSCs) are defined as reprogrammed somatic cells
exhibiting embryonic stem cell characteristics. Since their discovery in 2006, efforts have …

[HTML][HTML] Inherent immunogenicity or lack thereof of pluripotent stem cells: implications for cell replacement therapy

A Chhabra - Frontiers in immunology, 2017 - frontiersin.org
Donor-specific induced pluripotent stem cells (iPSCs) offer opportunities for personalized
cell replacement therapeutic approaches due to their unlimited self-renewal potential and …

Modulation of human allogeneic and syngeneic pluripotent stem cells and immunological implications for transplantation

SD Sackett, ME Brown, DM Tremmel, T Ellis… - Transplantation …, 2016 - Elsevier
Tissues derived from induced pluripotent stem cells (iPSCs) are a promising source of cells
for building various regenerative medicine therapies; from simply transplanting cells to …

Applications of iPSCs in cancer research: supplementary issue: stem cell biology

JJ Kim - Biomarker insights, 2015 - journals.sagepub.com
Induced pluripotent stem cells (iPSCs) derived from reprogrammed somatic cells are
emerging as one of the most versatile tools in biomedical research and pharmacological …

Cells derived from iPSC can be immunogenic—Yes or No?

J Cao, X Li, X Lu, C Zhang, H Yu, T Zhao - Protein & cell, 2014 - academic.oup.com
The induced pluripotent stem cells (iPSCs), derived by ectopic expression of reprogramming
factors in somatic cells, can potentially provide unlimited autologous cells for regenerative …