Chronic vulnerability to relapse is a formidable challenge for the treatment of drug addiction.
The neurobiological basis of relapse and its prevention has, therefore, attracted major …

Memory reconsolidation is the process by which memories, destabilised at retrieval, require
restabilisation to persist in the brain. It has been demonstrated that even old, well …

Drug addiction is characterized by persistent relapse vulnerability during abstinence. In
abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts …

The author provides a commentary on a series of articles published on relapse to substance
abuse. The following points summarize this commentary: animal and human studies of drug …

Reinstatement of drug-seeking behavior after extinction constitutes a potential animal model
of relapse to drug abuse. In a typical reinstatement experiment, previously drug-trained rats …

Drug addiction is a chronic disorder characterized by a high rate of relapse following
detoxification. There are two main versions of the reinstatement model that are employed to …

There is a good deal of clinical evidence suggesting that compulsion to resume drug taking
is an important part of the addiction syndrome. The symptoms comprising motivation to …

Rationale The neural circuitry subserving cocaine-seeking after extinction vs abstinence
alone requires different constituent brain structures. Spontaneous recovery of cocaine …

Rationale and objectives We previously found time dependent increases, or incubation, of
cocaine seeking induced by re-exposure to cocaine cues over withdrawal periods of up to 3 …

Contextual stimuli associated with drug exposure can modulate various effects of drugs, but
little is known about their role in relapse to drug seeking. Using a renewal procedure, the …