Aversive life events represent one of the main risk factors for the development of many
psychiatric diseases, but the interplay between environmental factors and genetic …

Regulation of hypothalamic-pituitary-adrenal (HPA) axis reactivity plays an important role in
the development of stress-related psychiatric disorders. FK506 binding protein 5 (FKBP5) …

Glucocorticoid hormones play a pivotal role in the response to stressful challenges. The
surge in glucocorticoid hormone secretion after stress needs to be tightly controlled with …

Background: Polymorphisms in the FK506 binding protein 5 (FKBP5) gene have been
shown to influence glucocorticoid receptor sensitivity, stress response regulation, and …

The review analyzes modern concepts about the control of various mechanisms of the
hippocampal neuroplasticity in adult mammals and humans by glucocorticoids …

The immunophilin FK506 binding protein 51 (FKBP51) has emerged as one of the most
intensely investigated proteins in stress-related mental disorders. It was originally …

Glucocorticoid (GC)-mediated negative feedback of the hypothalamic-pituitary-adrenal
(HPA) axis, the body's physiological stress response system, is tightly regulated and …

Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-
adrenal (HPA) axis is a fundamental component of multiple stress-related diseases …

Elisabeth B. Binder, The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the
pathogenesis and therapy of affective and anxiety disorders, Psychoneuroendocrinology …

Chronic stress is increasingly considered to be a main risk factor for the development of a
variety of psychiatric diseases such as depression. This is further supported by an impaired …