FKBP5 regulates the cortisol-binding affinity and nuclear translocation of the glucocorticoid
receptor. Polymorphisms at the FKBP5 locus have been associated with increased …

As the cerebellar molecular stress response is understudied, we assessed protein
expression levels of hypothalamic-pituitary-adrenal (HPA) axis regulators and …

This review addresses the molecular mechanisms of corticotropin-releasing factor (CRF)
regulation in the hypothalamus under stress and stress resilience. CRF in the hypothalamus …

BACKGROUND: The most consistent biological finding in patients with depression is a
hyperactivity of the hypothalamic–pituitary–adrenal (HPA)-axis, which might be caused by …

Childhood trauma has been proposed to increase vulnerability to develop psychopathology
in part through an altered cortisol stress response. Research in rats has suggested that this …

Responding to different dynamic levels of stress is critical for mammalian survival. Disruption
of mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) signaling is proposed to …

Glucocorticoid receptors (GR) mediate the direct effects of glucocorticoids released in
response to stress and the regulation of the hypothalamic-pituitary-adrenocortical (HPA) …

Optimal regulation of the stress response is a prerequisite for adaptation, homeostasis, and
health. There are two modes of operation in the stress response. First, an immediate …

It has been postulated that hyperactive glycogen synthase kinase-3 (GSK-3) is an important
factor in the pathogenesis of depression, and that this enzyme also contributes to the …

Background Disruption of the glucocorticoid negative feedback system evoked in animals by
chronic stress can be induced by downregulation of glucocorticoid receptors (GRs) in …