Objective Alterations in DNA methylation patterns have been found to correlate with several
diseases including osteoarthritis (OA). The aim of this study was to identify, for the first time …

Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints
resulting from the age-associated loss of cartilage. Well-powered genetic studies have …

Subchondral bone plays a key role in the development of osteoarthritis, however,
epigenetics of subchondral bone has not been extensively studied. In this study, we …

Difficulty in obtaining bone tissue is an obstacle to studying epigenetics to understand gene–
environment interactions, and their role in disease pathogenesis. Blood is an obvious …

Genetic and environmental determinants of skeletal phenotypes such as bone mineral
density (BMD) may converge through the epigenome, providing a tool to better understand …

Objective To identify osteoarthritis (OA) progression–modulating pathways in articular
cartilage and their respective regulatory epigenetic and genetic determinants in end‐stage …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …

The aim of this study is to identify osteoarthritis (OA)-associated differentially methylated
genes in human articular chondrocytes from patients with OA. DNA methylation profiling of …

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of
cartilage within articular joints. Although it is a leading cause of disability, there are no …