Osteoarthritis is a complex degenerative joint disease. Here, we investigate matched
genotype and methylation profiles of primary chondrocytes from macroscopically intact (low …

Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …

Objective The aim of this work was to characterize the genome-wide DNA methylation profile
of cartilage from three regions of tibial plateau isolated from patients with primary knee …

The development of osteoarthritis (OA) depends on genetic and environmental factors,
which influence the biology of the chondrocyte via epigenetic regulation. Changes within the …

Chronic low back pain (cLBP) that cannot be attributable to a specific pathoanatomical
change is associated with high personal and societal costs. Still, the underlying mechanism …

Osteoporosis is one of the most common age‐related progressive bone diseases in elderly
people. Approximately one in three women and one in five men are predisposed to …

Osteoarthritis (OA) is a common complex disease of high public health burden. OA is
characterized by the degeneration of affected joints leading to pain and reduced mobility …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …

Objective To examine the genome‐wide distribution of hydroxymethylated cytosine (5hmC)
in osteoarthritic (OA) and normal chondrocytes in order to investigate the effect on OA …

Epigenetic regulation of immune cell types could be critical for the development and
maintenance of autoimmune diseases like rheumatoid arthritis (RA). B cells are highly …