Objective Primary Sjögren's syndrome (SS) is a systemic autoimmune disease with
incompletely understood etiology. This study was undertaken to investigate the role of …

Objective The lack of accurate biomarkers to predict knee osteoarthritis (OA) progression is
a key unmet need in OA clinical research. The objective of this study was to develop …

Objective To investigate whether the changes in collagen gene expression in osteoarthritic
(OA) human chondrocytes are associated with changes in the DNA methylation status in the …

Osteoporosis is an age‐related metabolic bone disease. Hence, osteoporotic patients might
suffer from molecular features of accelerated aging, which is generally reflected by specific …

Epigenetic mechanisms integrate genetic and environmental causes of disease, but
comprehensive genome-wide analyses of epigenetic modifications have not yet …

Objective Human articular chondrocytes do not express COL10A1 and do not undergo
hypertrophy except in close vicinity to subchondral bone. In contrast, chondrocytes produced …

Introduction: Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic
inflammation of the joints. Recent evidence indicated the epigenetic changes may contribute …

OBJECTIVE: To review the current knowledge of the mechanism of DNA methylation, its
association with transcriptional silencing, possible mechanisms of hyper-and …

Abstract Purpose of Review Bone remodeling is a diverse field of study with many direct
clinical applications; past studies have implicated epigenetic alterations as key factors of …

Background Recent achievement in genetics and epigenetics has led to the exploration of
the pathogenesis of systemic lupus erythematosus (SLE). Identification of differentially …