We reported previously that the expression of Wnt-related genes is lower in osteoporotic hip
fractures than in osteoarthritis. We aimed to confirm those results by analyzing β-catenin …

Background DNA methylation is a key epigenetic mechanism for driving and stabilizing cell-
fate decisions. Local deposition and removal of DNA methylation are tightly coupled with …

Genetic and epigenetic changes contribute to deregulation of gene expression and
development of human cancer. Changes in DNA methylation are key epigenetic factors …

DNA methylation is an important epigenetic modification that is known to be altered in
rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter …

Aberrant methylation of genomic DNA has been reported in many cancers. Specific DNA
methylation patterns have been shown to provide clinically useful prognostic information …

DNA methylation is one of the most important epigenetic mechanisms in regulating gene
expression. Genome hypermethylation has been proposed as a critical mechanism in …

Aim: Although aberrant DNA methylation has been described in rheumatoid arthritis (RA), no
studies have interrogated this epigenetic modification in early disease. Following recent …

Altered genome methylation is a hallmark of human malignancies. In this study, high-
throughput analyses of concordant gene methylation and expression events were performed …

Background Aberrant DNA methylation may promote prostate carcinogenesis. We
investigated epigenome‐wide DNA methylation profiles in prostate cancer (PCa) compared …

The combination of the obesity epidemic and an aging population presents growing
challenges for the healthcare system. Obesity and aging are major risk factors for a diverse …