Orthodontic tooth movement elicits alveolar bone remodeling and orofacial pain that is
manifested by tooth mechanical hyperalgesia. Nerve growth factor (NGF) is upregulated in …

This study aimed to explore the role of acid-sensing ion channel 3 (ASIC3) in the modulation
of tooth mechanical hyperalgesia induced by orthodontic tooth movement. In male Sprague …

Tooth movements associated with orthodontic treatment often cause tooth pain. However,
the detailed mechanism remains unclear. Here, we examined the involvement of periodontal …

Objectives: This study aimed to clarify the roles of Acid-sensing ion channel 3 (ASIC3) in
orofacial pain following experimental tooth movement. Materials and methods: Sixty male …

The nerve growth factor (NGF) plays an important role in the regulation of neuropathic pain.
It has been demonstrated that calcitonin gene-related peptide (CGRP), a well-known …

The transient receptor potential ankyrin repeat 1 (TRPA1) channel is believed to be involved
in many forms of acute and chronic hyperalgesia. Nerve Growth Factor (NGF) regulates …

Orthodontic force produces mechanical irritation and inflammation in the periodontium,
which is inevitably accompanied by pain. Despite its prevalence, treatment of orthodontic …

Objectives Orthodontic tooth movement (OTM) increases sympathetic and sensory
neurological markers in periodontal tissue. However, the relationship between the …

Orthodontic force produces mechanical irritation and localized inflammation in the
periodontium, which causes pain in most patients. Nocifensive behaviors resulting from …

The nerve growth factor (NGF) and calcitonin gene-related peptide (CGRP) play a crucial
role in the regulation of orofacial pain. It has been demonstrated that CGRP increases …