Glucagon and its partner insulin are dually linked in both their secretion from islet cells and
their action in the liver. Glucagon signaling increases hepatic glucose output, and …

Insulin and glucagon exert opposing effects on glucose metabolism and, consequently,
pancreatic islet β-cells and α-cells are considered functional antagonists. The intra-islet …

Pancreatic α-cells are the major source of glucagon, a hormone that counteracts the
hypoglycemic action of insulin and strongly contributes to the correction of acute …

Since the discovery of glucagon 100 years ago, the hormone, and the pancreatic islet alpha
cells that produce it, have remained enigmatic relative to insulin producing beta cells …

Glucagon is usually viewed as an important counterregulatory hormone in glucose
metabolism, with actions opposing those of insulin. Evidence exists that shows glucagon is …

Amino acids stimulate the secretion of glucagon, and glucagon receptor signaling regulates
amino acid catabolism via ureagenesis, together constituting the liver-α cell axis. Impairment …

Both glucagon and glucagon‐like peptide‐1 (GLP‐1) are produced from proglucagon
through proteolytic cleavage. Blocking glucagon action increases the circulating levels of …

Glucose homeostasis is precisely regulated by glucagon and insulin, which are released by
pancreatic α-and β-cells, respectively. While β-cells have been the focus of intense …

Glucagon and insulin are the main regulators of blood glucose. While the actions of insulin
are extensively mapped, less is known about glucagon. Besides glucagon's role in glucose …

In normal physiology, glucagon from pancreatic alpha cells plays an important role in
maintaining glucose homeostasis via its regulatory effect on hepatic glucose production …