Synopsis Defibrotide is a deoxyribonucleic acid derivative extracted from mammalian
organs, which has been developed for the treatment of a number of vascular disorders. It …

Defibrotide is the sodium salt of a polydeoxyribonucleotide extracted from mammalian
organs and prepared by controlled depolymerization of deoxyribonucleic acid (DNA). The …

The drug named defibrotide (DFT) has been studied for many years. It has been shown to
possess many activities: profibrinolytic, antithrombotic–thrombolytic, antiischemic (heart …

Fibrinolytic activity has been shown to be reduced in many vascular diseases, including
hepatic veno-occlusive disease after stem cell transplantation, a microangiopathy …

Defibrotide is a polynucleotide extracted from mammalian lung, which shows antithrombotic
and anti-ischaemic activity in animals, probably related to stimulation of fibrinolysis and/or …

An extensive study of the pharmacokinetics and the pharmacokinetics of the profibrinolytic
activity of Defibrotide (D) in the rabbit has been made. A two compartment model was used …

The effect of chronic oral defibrotide on platelet function, vascular PG1 2 generation,
atherosclerotic plaque formation and serum lipids was studied in rabbits. The animals were …

Defibrotide, a polydeoxyribonucleotide extracted from mammalian organs (laboratory code
Fraction P), displays antithrombotic activity after oral administration on different animal …

Defibrotide (DF) is a polydisperse mixture of 90% single-stranded oligonucleotides with anti-
thrombotic and anti-apoptotic functions. DF is used in the treatment of endothelial …

Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially
life-threatening complication of conditioning during hematopoietic stem cell transplantation …