The inclusion of an azaspiroketal Mannich base in the membrane targeting antitubercular 6-
methoxy-1-n-octyl-1 H-indole scaffold resulted in analogs with improved selectivity and …

Chemistry campaigns identified amphiphilic indolyl Mannich bases as novel membrane-
permeabilizing antimycobacterials. Spiroketal analogs of this series showed increased …

Antibacterials that disrupt cell membrane function have the potential to eradicate “persister”
organisms and delay the emergence of resistance. Here we report the antimycobacterial …

A cellular activity-based screen on Mycobacterium tuberculosis (Mtb) H37Rv using a
focused library from the AstraZeneca corporate collection led to the identification of 2 …

Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here we found
that modifying the incipient scaffold by amide–amine substitution and replacing the indole …

A series of alkynyl-containing maleimides with potent anti-tuberculosis (TB) activity was
developed through a rigid group substitution strategy based on our previous study …

About 100,000 deaths are attributed annually to infections with methicillin-resistant
Staphylococcus aureus (MRSA) despite concerted efforts toward vaccine development and …

Mycobacterium tuberculosis is an important global pathogen for which new drugs are
urgently required. The ability of the organism to survive and multiply within macrophages …

We screened a series of 4-anilinoquinolines and 4-anilinoquinazolines and identified novel
inhibitors of Mycobacterium tuberculosis (Mtb). The focused 4-anilinoquinoline/quinazoline …

The treacherous nature of tuberculosis (TB) combined with the ubiquitous presence of the
drug-resistant (DR) forms pose this disease as a growing public health menace. Therefore, it …