Quantitative comparison of 3D third harmonic generation and fluorescence microscopy images

Z Zhang, NV Kuzmin, ML Groot… - Journal of …, 2018 - Wiley Online Library
Third harmonic generation (THG) microscopy is a label‐free imaging technique that shows
great potential for rapid pathology of brain tissue during brain tumor surgery. However, the …

Third harmonic generation imaging for fast, label-free pathology of human brain tumors

NV Kuzmin, P Wesseling, PCW Hamer… - Biomedical optics …, 2016 - opg.optica.org
In brain tumor surgery, recognition of tumor boundaries is key. However, intraoperative
assessment of tumor boundaries by the neurosurgeon is difficult. Therefore, there is an …

Quantitative third harmonic generation microscopy for assessment of glioma in human brain tissue

Z Zhang, JC de Munck, N Verburg… - Advanced …, 2019 - Wiley Online Library
Distinguishing tumors from normal brain cells is important but challenging in glioma surgery
due to the lack of clear interfaces between the two. The ability of label‐free third harmonic …

Third Harmonic Generation microscopy as a diagnostic tool for the investigation of microglia BV-2 and breast cancer cells activation.

E Gavgiotaki, G Filippidis… - … on Biomedical Optics, 2015 - opg.optica.org
Nonlinear optical imaging techniques have created new opportunities of research in the
biomedical field. Specifically, Third Harmonic Generation (THG) seems to be a suitable …

Label-free live brain imaging and targeted patching with third-harmonic generation microscopy

S Witte, A Negrean, JC Lodder… - Proceedings of the …, 2011 - National Acad Sciences
The ability to visualize neurons inside living brain tissue is a fundamental requirement in
neuroscience and neurosurgery. Especially the development of a noninvasive probe of …

Third-Harmonic Generation Microscopy For Label-Free Brain Imaging

S Witte, NV Kuzmin, A Negrean, JC Lodder… - Biomedical …, 2012 - opg.optica.org
Third-Harmonic Generation Microscopy For Label-Free Brain Imaging Page 1 BSu4B.4.pdf
Biomedical Optics and 3D Imaging OSA 2012 Third-Harmonic Generation Microscopy For …

Quantitative third-harmonic generation imaging of mouse visual cortex areas reveals correlations between functional maps and structural substrates

M Yildirim, M Hu, NM Le, H Sugihara… - Biomedical Optics …, 2020 - opg.optica.org
The structure of brain regions is assumed to correlate with their function, but there are very
few instances in which the relationship has been demonstrated in the live brain. This is due …

Label-free three-dimensional imaging of cell nucleus using third-harmonic generation microscopy

J Lin, W Zheng, Z Wang, Z Huang - Applied Physics Letters, 2014 - pubs.aip.org
We report the implementation of the combined third-harmonic generation (THG) and two-
photon excited fluorescence (TPEF) microscopy for label-free three-dimensional (3-D) …

Lipid content evaluation of Drosophila tumour associated haemocytes through Third Harmonic Generation measurements

M Mari, C Voutyraki, E Zacharioudaki… - Journal of …, 2023 - Wiley Online Library
Non‐linear microscopy is a powerful imaging tool to examine structural properties and
subcellular processes of various biological samples. The competence of Third Harmonic …

Harmonic generation microscopy 2.0: new tricks empowering intravital imaging for neuroscience

H Lim - Frontiers in Molecular Biosciences, 2019 - frontiersin.org
Optical harmonic generation, eg, second-(SHG) and third-harmonic generation (THG),
provides intrinsic contrasts for three-dimensional intravital microscopy. Contrary to two …