The endoplasmic reticulum (ER) is a well-orchestrated protein-folding machine composed of
protein chaperones, proteins that catalyze protein folding, and sensors that detect the …

Significance: The endoplasmic reticulum (ER) is a specialized organelle for the folding and
trafficking of proteins, which is highly sensitive to changes in intracellular homeostasis and …

The endoplasmic reticulum (ER) is the principal cellular organelle in which correct folding
and maturation of transmembrane, secretory, and ER-resident proteins occur. Research …

Cellular mechanisms governing redox homeostasis likely involve their integration with other
stresses. Endoplasmic reticulum (ER) stress triggers complex adaptive or proapoptotic …

The endoplasmic reticulum (ER) is the first compartment of secretory pathway. It plays a
major role in ER chaperone-assisted folding and quality control, including post-translational …

The endoplasmic reticulum (ER) is a multifunctional organelle within which protein folding,
lipid biosynthesis, and calcium storage occurs. Perturbations such as energy or nutrient …

Endoplasmic reticulum (ER) is a dynamic organelle orchestrating the folding and post-
translational maturation of almost all membrane proteins and most secreted proteins. These …

The endoplasmic reticulum (ER) is an essential organelle of eukaryotic cells. Its main
functions include protein synthesis, proper protein folding, protein modification, and the …

Disruption of protein folding in the endoplasmic reticulum (ER) causes unfolded proteins to
accumulate, triggering the unfolded protein response (UPR). UPR outputs in turn decrease …

A variety of debilitating diseases including diabetes, Alzheimer's, Huntington's, Parkinson's,
and prion-based diseases are linked to stress within the endoplasmic reticulum (ER). Using …