In the developing or regenerating nervous system, migrating growth cones are exposed to
regulatory molecules that positively and/or negatively affect guidance. Chondroitin sulfate …

The proteoglycans are multifunctional macromolecules composed of a core polypeptide and
a variable number of glycosaminoglycan chains. The structural diversity and complexities of …

A large brain-specific chondroitin sulfate proteoglycan, identified with monoclonal antibody
6B4 (6B4 proteoglycan/phosphacan), was isolated from rat brain. Soluble proteoglycans in …

During early postnatal development of the CNS, neuronal networks are configured through
the formation, elimination, and remodeling of dendritic spines, the sites of most excitatory …

The primary mediators of cell migration during development, wound healing and metastasis,
are receptors of the integrin family. In the developing and regenerating nervous system …

We have recently shown that the large hyaluronan-aggregating chondroitin sulfate
proteoglycan from cartilage (PG-LA) is unfavorable as a substrate for neural crest cell …

Background The extracellular matrix (ECM) of the brain is rich in glycosaminoglycans such
as chondroitin sulfate (CS) and hyaluronan. These glycosaminoglycans are organized into …

Chondroitin sulphate proteoglycans in the extracellular matrix restrict plasticity in the adult
central nervous system and their digestion with chondroitinase reactivates plasticity …

Proteoglycans are of two main types, chondroitin sulfate (CSPGs) and heparin sulfate
(HSPGs). The CSPGs act mainly as barrier-forming molecules, whereas the HSPGs stabilise …

Background Proteoglycan (PG) in the extracellular matrix (ECM) of the central nervous
system (CNS) may act as a barrier for neurite elongation in a growth tract, and regulate other …