The localization of aggrecan and mRNA splice variants of versican in the developing rat
central nervous system has been examined by using specific polyclonal antibodies to the …

Neurocan is a chondroitin sulfate proteoglycan of the lectican family and a component of the
extracellular matrix of the central nervous system. It is mainly expressed during modeling …

The extracellular matrix (ECM) of the nervous system regulates numerous events during
development, from neurogenesis and gliogenesis to circuitry formation, as well as in …

Thrombospondin (TSP) is a multifunctional extracellular matrix protein that plays a role in
neuronal migration and axonal outgrowth in the developing central nervous system. In the …

After an injury to the adult mammalian central nervous system (CNS), a variety of growth-
inhibitory molecules are upregulated. A glial scar forms at the site of injury and is composed …

Thrombospondins are extracellular-matrix glycoproteins implicated in the control of
synaptogenesis and neurite growth. Previous microarray studies suggested that one gene of …

Perineuronal nets (PNNs) are lattice‐like extracellular matrix structures composed of
chondroitin sulfate proteoglycans (CSPGs). The appearance of PNNs parallels the decline …

As a step in defining the molecular environment for development of the mammalian cerebral
cortex, we have used immunohistochemistry to analyze the distribution and remodeling of …

Astrocytes play an important role in neuronal development through the release of soluble
factors that affect neuronal maturation. Shotgun proteomics followed by gene ontology …

The adult neural parenchyma contains a distinctive extracellular matrix that acts as a barrier
to cell and neurite motility. Nonneural tumors that metastasize to the central nervous system …