Long-term alleviation of allodynia-like behaviors by intrathecal implantation of bovine chromaffin cells in rats with spinal cord injury

W Yu, JX Hao, XJ Xu, J Saydoff, A Haegerstrand… - Pain, 1998 - Elsevier
Adrenal chromaffin cells produce analgesic substances, such as catecholamines and
enkephalins, and intrathecal (it) implantation of either allografted adrenal tissue or …

Immunoisolating encapsulation of intrathecally implanted bovine chromaffin cells prolongs their survival and produces anti‐allodynic effect in spinally injured rats

W Yu, JX Haoa, XJ Xu, J Saydoff… - … Journal of Pain, 1998 - Wiley Online Library
We have previously reported that intrathecal (it) implantation of bovine chromaffin cells has
an anti‐allodynic effect in a rat model of mechanical and cold allodynia‐like neuropathic …

Intrathecal implants of bovine chromaffin cells alleviate mechanical allodynia in a rat model of neuropathic pain

I Décosterd, E Buchser, N Gilliard, J Saydoff, AD Zurn… - Pain, 1998 - Elsevier
Intrathecal implants of adrenal chromaffin cells are known to release analgesic substances
such as catecholamines and opioid peptides. In the present study, bovine chromaffin cells …

Alleviation of neuropathic pain symptoms by xenogeneic chromaffin cell grafts in the spinal subarachnoid space

AT Hama, J Sagen - Brain research, 1994 - Elsevier
Recent data have suggested that adrenal medullary tissue allografts in the spinal cord
subarachnoid space, by releasing catecholamines and opioid peptides, attenuate …

Intrathecal implants of microencapsulated xenogenic chromaffin cells provide a long-term source of analgesic substances

Y Jeon, K Kwak, S Kim, Y Kim, J Lim, W Baek - Transplantation …, 2006 - Elsevier
Adrenal medullary chromaffin cells secrete several neuroactive substances including
catecholamines and opioid peptides that produce analgesic effects in the central nervous …

Transplants of immunologically isolated xenogeneic chromaffin cells provide a long-term source of pain-reducing neuroactive substances

J Sagen, H Wang, PA Tresco… - Journal of …, 1993 - Soc Neuroscience
Adrenal medullary chromaffin cells are a potential source of neuroactive substances for
transplantation into the CNS to alleviate neurochemical deficits. In particular, work in our …

Transplants of adrenal medullary chromaffin cells reduce forelimb and hindlimb allodynia in a rodent model of chronic central pain after spinal cord hemisection injury

BC Hains, KM Chastain, AW Everhart, DJ McAdoo… - Experimental …, 2000 - Elsevier
In the majority of patients, spinal cord injury (SCI) results in abnormal pain syndromes in
which nonnoxious stimuli become noxious (allodynia). To reduce allodynia, it would be …

Intrathecal polymer-encapsulated bovine adrenal chromaffin cells fail to produce analgesic effects in the hotplate and formalin test

MD Lindner, JM Francis, JA Saydoff - Experimental neurology, 2000 - Elsevier
Numerous publications have reported that adrenal chromaffin cells implanted in the lumbar
intrathecal space produce analgesic effects in rodent models of pain. The present study was …

Analgesia induced by isolated bovine chromaffin cells implanted in rat spinal cord.

J Sagen, GD Pappas… - Proceedings of the …, 1986 - National Acad Sciences
Chromaffin cells synthesize and secrete several neuroactive substances, including
catecholamines and opioid peptides, that, when injected into the spinal cord, induce …

Intraventricular encapsulated calf adrenal chromaffin cells: viable for at least 500 days in vivo without detectable adverse effects on behavioral/cognitive function or …

MD Lindner, MA Plone, B Frydel… - Restorative …, 1997 - content.iospress.com
Numerous studies have reported that adrenal chromaffin cell transplants, including
encapsulated xenogeneic adrenal chromaffin cells, have analgesic effects. However, in …