The progressive aging of the population and the fact that Parkinson's disease currently does
not have any curative treatment turn out to be essential issues in the following years, where …

Although Parkinson's disease is the most common neurodegenerative movement disorder,
the mechanisms of pathogenesis remain poorly understood. Recent findings have shown …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder that
affects about 1% of the population worldwide. Despite significant advances in the …

Autophagy is an essential catabolic mechanism that delivers misfolded proteins and
damaged organelles to the lysosome for degradation. Autophagy pathways include …

Cellular quality control systems have gained much attention in recent decades. Among
these, autophagy is a natural self-preservation mechanism that continuously eliminates toxic …

Converging evidence from genetic, pathological and experimental studies have increasingly
suggested an important role for autophagy impairment in Parkinson's Disease (PD). Genetic …

Parkinson's disease (PD) is a paradigmatic example of neurodegenerative disorder with a
critical role of oxidative stress in its etiopathogenesis. Genetic susceptibility factors of PD …

Autophagy is a term used to describe the process by which lysosomes degrade intracellular
components. Known originally as an adaptive response to nutrient deprivation, autophagy …

Macroautophagy, an evolutionary conserved catabolic process in the eukaryotic cell,
regulates cellular homeostasis and plays a decisive role in self-engulfing proteins, protein …

Autophagy is a cellular quality control mechanism crucial for neuronal homeostasis. Defects
in autophagy are critically associated with mechanisms underlying Parkinson´ s disease …