Giving drugs a second chance: overcoming regulatory and financial hurdles in repurposing approved drugs as cancer therapeutics

JJ Hernandez, M Pryszlak, L Smith, C Yanchus… - Frontiers in …, 2017 - frontiersin.org
The repositioning or “repurposing” of existing therapies for alternative disease indications is
an attractive approach that can save significant investments of time and money during drug …

Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects

R Mohi-Ud-Din, A Chawla, P Sharma, PA Mir… - European journal of …, 2023 - Springer
Cancer poses a significant global health challenge, with predictions of increasing
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …

Drug Repurposing in Cancer

NR Shruthi, M Samatha Jain, H Ganesan… - Drug Repurposing for …, 2023 - Springer
The discovery of drug compounds has a long history in drug repurposing, notably by
fortuitous findings. It has taken a new path in the creation of novel therapeutics based on …

Drug repurposing for cancer therapy in the era of precision medicine

K KW To, WCS Cho - Current Molecular Pharmacology, 2022 - benthamdirect.com
Drug repurposing refers to the identification of clinically approved drugs with the known
safety profiles and defined pharmacokinetic properties for new indications. Despite the …

Introduction: Repurposed Drugs: Teaching an Old Dog New Tricks

VP Sukhatme - The Cancer Journal, 2019 - journals.lww.com
Why is this a timely topic for the oncology community? The cost of new cancer drugs is
increasing rapidly and is currently in the range of $100,000 to $150,000 per year. Thus, this …

Unlocking hidden potential: advancements, approaches, and obstacles in repurposing drugs for cancer therapy

FR Weth, GB Hoggarth, AF Weth, E Paterson… - British Journal of …, 2024 - nature.com
High rates of failure, exorbitant costs, and the sluggish pace of new drug discovery and
development have led to a growing interest in repurposing “old” drugs to treat both common …

Old wine in new bottles: Drug repurposing in oncology

M Antoszczak, A Markowska, J Markowska… - European Journal of …, 2020 - Elsevier
Increasing costs, much time consumption and high risk of failure associated with the process
of de novo development of new anticancer drugs have prompted the pharmaceutical …

Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics

A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Repurposing drugs in oncology: next steps

C Verbaanderd, L Meheus, I Huys, P Pantziarka - Trends in cancer, 2017 - cell.com
The repurposing of existing non-cancer drugs is a potential source of new treatment options
for cancer patients with high unmet medical needs. While scientific research is progressing …

[HTML][HTML] Repurposing non-oncology small-molecule drugs to improve cancer therapy: Current situation and future directions

L Fu, W Jin, J Zhang, L Zhu, J Lu, Y Zhen… - … Pharmaceutica Sinica B, 2022 - Elsevier
Drug repurposing or repositioning has been well-known to refer to the therapeutic
applications of a drug for another indication other than it was originally approved for …