Repurposing drugs in oncology: From candidate selection to clinical adoption

P Pantziarka, C Verbaanderd, I Huys, G Bouche… - Seminars in Cancer …, 2021 - Elsevier
Drug repurposing is a strategy that aims to develop novel cancer treatments through the
reuse of existing medicines developed in other disease areas. Such a strategy includes the …

Repackaging FDA-approved drugs for degenerative diseases: promises and challenges

JL Cummings, K Zhong - Expert Review of Clinical Pharmacology, 2014 - Taylor & Francis
Repurposing refers to the therapeutic use of a drug or drug candidate for a disease other
than that for which it was originally intended. Repurposing is attractive as a drug …

Repurposing metabolic regulators: antidiabetic drugs as anticancer agents

Y Dhas, N Biswas, D MR, LD Jones, S Ashili - Molecular Biomedicine, 2024 - Springer
Drug repurposing in cancer taps into the capabilities of existing drugs, initially designed for
other ailments, as potential cancer treatments. It offers several advantages over traditional …

Drug Repurposing: Then, Now, and in the Future

HAM Mucke - Drug Repurposing, 2024 - drugrepocentral.scienceopen.com
Contrary to the definition of a drug, drug repurposing usually involves the redevelopment of
an active pharmaceutical ingredient (API) for a substantially different medical use; only …

Drug repositioning in sarcomas and other rare tumors

ATJ Lee, PH Huang, SM Pollack, RL Jones - EBioMedicine, 2016 - thelancet.com
The exploration and identification of new anti-cancer therapeutic indications for an approved
drug already in use, or for a drug that was shelved for non-safety reasons in early clinical …

Drug repurposing in oncology, an attractive opportunity for novel combinatorial regimens

P Falvo, S Orecchioni, S Roma… - Current Medicinal …, 2021 - ingentaconnect.com
The costs of developing, validating and buying new drugs are dramatically increasing. On
the other hand, sobering economies have difficulties in sustaining their healthcare systems …

Is drug repurposing really the future of drug discovery or is new innovation truly the way forward?

C Gil, A Martinez - Expert opinion on drug discovery, 2021 - Taylor & Francis
Drug discovery process is a costly and time-consuming task. An average of 12–15 years is
required for a drug to be approved [1]. The investment required to get it increases …

[PDF][PDF] Drug repositioning: extracting added value from prior R&D investments

HAM Mucke - Insight Pharma Reports, 2010 - researchgate.net
Drug repurposing (an approach to drug development that is also known as drug
repositioning, reprofiling, or retasking) has become a matter of intense interest during the …

Epidrug repurposing: discovering new faces of old acquaintances in cancer therapy

M Montalvo-Casimiro, R González-Barrios… - Frontiers in …, 2020 - frontiersin.org
Gene mutations are strongly associated with tumor progression and are well known in
cancer development. However, recently discovered epigenetic alterations have shown the …

Drug Repurposing for Treatment of Cancer 66

A Mishra, P Gupta - Handbook of Oncobiology: From Basic to Clinical …, 2024 - Springer
Drug repurposing is a ray of hope for therapy of various diseases including cancer. Since
historical times, drugs like nitrogen mustards, chlorambucil, etc. have been repurposed in …