Repurposing drugs in oncology: From candidate selection to clinical adoption
P Pantziarka, C Verbaanderd, I Huys, G Bouche… - Seminars in Cancer …, 2021 - Elsevier
Drug repurposing is a strategy that aims to develop novel cancer treatments through the
reuse of existing medicines developed in other disease areas. Such a strategy includes the …
reuse of existing medicines developed in other disease areas. Such a strategy includes the …
Repackaging FDA-approved drugs for degenerative diseases: promises and challenges
JL Cummings, K Zhong - Expert Review of Clinical Pharmacology, 2014 - Taylor & Francis
Repurposing refers to the therapeutic use of a drug or drug candidate for a disease other
than that for which it was originally intended. Repurposing is attractive as a drug …
than that for which it was originally intended. Repurposing is attractive as a drug …
Repurposing metabolic regulators: antidiabetic drugs as anticancer agents
Drug repurposing in cancer taps into the capabilities of existing drugs, initially designed for
other ailments, as potential cancer treatments. It offers several advantages over traditional …
other ailments, as potential cancer treatments. It offers several advantages over traditional …
Drug Repurposing: Then, Now, and in the Future
HAM Mucke - Drug Repurposing, 2024 - drugrepocentral.scienceopen.com
Contrary to the definition of a drug, drug repurposing usually involves the redevelopment of
an active pharmaceutical ingredient (API) for a substantially different medical use; only …
an active pharmaceutical ingredient (API) for a substantially different medical use; only …
Drug repositioning in sarcomas and other rare tumors
The exploration and identification of new anti-cancer therapeutic indications for an approved
drug already in use, or for a drug that was shelved for non-safety reasons in early clinical …
drug already in use, or for a drug that was shelved for non-safety reasons in early clinical …
Drug repurposing in oncology, an attractive opportunity for novel combinatorial regimens
P Falvo, S Orecchioni, S Roma… - Current Medicinal …, 2021 - ingentaconnect.com
The costs of developing, validating and buying new drugs are dramatically increasing. On
the other hand, sobering economies have difficulties in sustaining their healthcare systems …
the other hand, sobering economies have difficulties in sustaining their healthcare systems …
Is drug repurposing really the future of drug discovery or is new innovation truly the way forward?
C Gil, A Martinez - Expert opinion on drug discovery, 2021 - Taylor & Francis
Drug discovery process is a costly and time-consuming task. An average of 12–15 years is
required for a drug to be approved [1]. The investment required to get it increases …
required for a drug to be approved [1]. The investment required to get it increases …
[PDF][PDF] Drug repositioning: extracting added value from prior R&D investments
HAM Mucke - Insight Pharma Reports, 2010 - researchgate.net
Drug repurposing (an approach to drug development that is also known as drug
repositioning, reprofiling, or retasking) has become a matter of intense interest during the …
repositioning, reprofiling, or retasking) has become a matter of intense interest during the …
Epidrug repurposing: discovering new faces of old acquaintances in cancer therapy
M Montalvo-Casimiro, R González-Barrios… - Frontiers in …, 2020 - frontiersin.org
Gene mutations are strongly associated with tumor progression and are well known in
cancer development. However, recently discovered epigenetic alterations have shown the …
cancer development. However, recently discovered epigenetic alterations have shown the …
Drug Repurposing for Treatment of Cancer 66
A Mishra, P Gupta - Handbook of Oncobiology: From Basic to Clinical …, 2024 - Springer
Drug repurposing is a ray of hope for therapy of various diseases including cancer. Since
historical times, drugs like nitrogen mustards, chlorambucil, etc. have been repurposed in …
historical times, drugs like nitrogen mustards, chlorambucil, etc. have been repurposed in …