Drug Repurposing: Uncovering New Uses for Existing Medications

S Showbharnikhaa, MKV MK - Journal of Pharma Insights and Research, 2023 - jopir.in
Drug repurposing, also known as drug repositioning or reprofiling, refers to the process of
identifying new therapeutic applications for existing drugs that were originally intended for …

Drug repurposing for cancer therapy, easier said than done

A Gonzalez-Fierro, A Dueñas-González - Seminars in cancer biology, 2021 - Elsevier
Drug repurposing for cancer therapy is currently a hot topic of research. Theoretically, in
contrast to the known hurdles of developing new molecular entities, the approach of …

Potential repurposing of oncology drugs for the treatment of Alzheimer's disease

W Araki - BMC medicine, 2013 - Springer
Alzheimer's disease (AD) is the most common form of neurodegenerative dementia,
affecting about 30 million people worldwide. Despite recent advances in understanding its …

The drug repurposing landscape from 2012 to 2017: evolution, challenges, and possible solutions

P Polamreddy, N Gattu - Drug Discovery Today, 2019 - Elsevier
Highlights•Drug repurposing gained momentum in the recent past.•Drug repurposing is a
promising strategy for rare disease drug discovery.•Drug repurposing resulted in fruitful …

Repurposing drugs in oncology: From candidate selection to clinical adoption

P Pantziarka, C Verbaanderd, I Huys, G Bouche… - Seminars in Cancer …, 2021 - Elsevier
Drug repurposing is a strategy that aims to develop novel cancer treatments through the
reuse of existing medicines developed in other disease areas. Such a strategy includes the …

[HTML][HTML] Drug repurposing: An effective strategy to accelerate contemporary drug discovery

P Zhan, B Yu, L Ouyang - Drug discovery today, 2022 - ncbi.nlm.nih.gov
Because of the high risk, substantial cost and slow pace of new drug discovery and
development, drug repurposing (also called repositioning, redirecting, reprofiling) is …

Repackaging FDA-approved drugs for degenerative diseases: promises and challenges

JL Cummings, K Zhong - Expert Review of Clinical Pharmacology, 2014 - Taylor & Francis
Repurposing refers to the therapeutic use of a drug or drug candidate for a disease other
than that for which it was originally intended. Repurposing is attractive as a drug …

Drug repurposing: far beyond new targets for old drugs

TI Oprea, J Mestres - The AAPS journal, 2012 - Springer
Repurposing drugs requires finding novel therapeutic indications compared to the ones for
which they were already approved. This is an increasingly utilized strategy for finding novel …

Drug repositioning in sarcomas and other rare tumors

ATJ Lee, PH Huang, SM Pollack, RL Jones - EBioMedicine, 2016 - thelancet.com
The exploration and identification of new anti-cancer therapeutic indications for an approved
drug already in use, or for a drug that was shelved for non-safety reasons in early clinical …

[HTML][HTML] Inventing new therapies without reinventing the wheel: the power of drug repurposing

A Papapetropoulos, C Szabo - British journal of pharmacology, 2018 - ncbi.nlm.nih.gov
Current drug development strategies devote extensive effort to identifying the molecular
mechanism of action of new drug candidates. Often, if more than one unrelated enzyme or …