[HTML][HTML] TAM receptors are pleiotropic inhibitors of the innate immune response
CV Rothlin, S Ghosh, EI Zuniga, MBA Oldstone… - Cell, 2007 - cell.com
The activation of Toll-like receptors (TLRs) in dendritic cells (DCs) triggers a rapid
inflammatory response to pathogens. However, this response must be tightly regulated …
inflammatory response to pathogens. However, this response must be tightly regulated …
Phosphatidylserine sensing by TAM receptors regulates AKT-dependent chemoresistance and PD-L1 expression
Abstract Tyro3, Axl, and Mertk (collectively TAM receptors) are three homologous receptor
tyrosine kinases that bind vitamin K–dependent endogenous ligands, Protein S (ProS), and …
tyrosine kinases that bind vitamin K–dependent endogenous ligands, Protein S (ProS), and …
Macrophage–tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands
T Schmidt, I Ben-Batalla, A Schultze… - Cellular and molecular life …, 2012 - Springer
Ample clinical and preclinical evidence indicates that macrophages interact with tumor cells
as well as with virtually all populations of host cells present in the tumor microenvironment …
as well as with virtually all populations of host cells present in the tumor microenvironment …
Expression of TAM-R in human immune cells and unique regulatory function of Mertk in IL-10 production by tolerogenic DC
P Giroud, S Renaudineau, L Gudefin, A Calcei… - Frontiers in …, 2020 - frontiersin.org
Tumor-infiltrating myeloid cells are a key component of the immune infiltrate often correlated
with a poor prognosis due to their capacities to sustain an immunosuppressive environment …
with a poor prognosis due to their capacities to sustain an immunosuppressive environment …
The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
The TYRO3, AXL (also known as UFO) and MERTK (TAM) family of receptor tyrosine
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
kinases (RTKs) are aberrantly expressed in multiple haematological and epithelial …
TAM family receptor kinase inhibition reverses MDSC-mediated suppression and augments anti–PD-1 therapy in melanoma
A Holtzhausen, W Harris, E Ubil, DM Hunter… - Cancer immunology …, 2019 - AACR
Myeloid cell receptor tyrosine kinases TYRO3, AXL, and MERTK and their ligands, GAS6
and PROTEIN S, physiologically suppress innate immune responses, including in the tumor …
and PROTEIN S, physiologically suppress innate immune responses, including in the tumor …
[HTML][HTML] Resolving inflammation by TAM receptor activation
JP Vago, FA Amaral, FAJ van de Loo - Pharmacology & Therapeutics, 2021 - Elsevier
The control of inflammation is strictly regulated to ensure the adequate intensity and duration
of an inflammatory response, enabling the removal of the trigger factors and the restoration …
of an inflammatory response, enabling the removal of the trigger factors and the restoration …
TAM receptors, Phosphatidylserine, inflammation, and Cancer
T Burstyn-Cohen, A Maimon - Cell Communication and Signaling, 2019 - Springer
The numerous and diverse biological roles of Phosphatidylserine (PtdSer) are featured in
this special issue. This review will focus on PtdSer as a cofactor required for stimulating …
this special issue. This review will focus on PtdSer as a cofactor required for stimulating …
Immuno-oncological efficacy of RXDX-106, a novel TAM (TYRO3, AXL, MER) family small-molecule kinase inhibitor
Y Yokoyama, ED Lew, R Seelige, EA Tindall, C Walsh… - Cancer Research, 2019 - AACR
Expression of the TAM (TYRO3, AXL, MER) family of receptor tyrosine kinases (RTK) has
been associated with cancer progression, metastasis, and drug resistance. In immune cells …
been associated with cancer progression, metastasis, and drug resistance. In immune cells …
Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer
CV Rothlin, JA Leighton, S Ghosh - Inflammatory bowel …, 2014 - academic.oup.com
Three receptor tyrosine kinases, Tyro3, Axl, and Mertk (TAM) and their ligands Gas6 and
Protein S, have emerged as potent negative regulators of innate immune responses. A …
Protein S, have emerged as potent negative regulators of innate immune responses. A …