The transforming and tumor growth–promoting properties of Axl, a member of the Tyro3, Axl,
and Mer (TAM) family of receptor tyrosine kinases (TAMRs), are well recognized. In contrast …

Macrophages are crucial innate immune cells that maintain tissue homeostasis and defend
against pathogens; however, their infiltration into tumors has been associated with adverse …

TAM receptors and the regulation of erythropoiesis in mice - PMC Back to Top Skip to main
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Restoration of one of the major physiological functions of the body's immune response, the
rejection of malignant cells, is a promising yet challenging task for cancer therapy …

Many apoptotic thymocytes are generated during the course of T cell selection in the thymus,
yet the machinery through which these dead cells are recognized and phagocytically …

The TAM family of proto-oncogenic receptor protein tyrosine kinases, comprising of TYRO3,
AXL, and MERTK, is implicated in many human cancers. Their activation leads to cancer cell …

Receptor tyrosine kinases (RTKs) are cell surface proteins that tightly regulate a variety of
downstream intra-cellular processes; ligand-receptor interactions result in cascades of …

Delineating the regulatory pathways governing TAM heterogeneity and activation could
present a novel frontier in cancer therapy. TAM targeting/repolarization is considered as a …

The TAM subfamily (Tyro3, Axl, MerTK) of receptor tyrosine kinases are implicated in several
cancers, where they have been shown to support primary tumorigenesis as well as …

Despite recent advances in activating immune cells to target tumors, the presence of some
immune cells, such as tumor-associated macrophages (TAMs) or tumor-associated …