This review summarizes current understanding of the mechanisms which mediate immune
glomerular injury in glomerulonephritis. Non-inflammatory lesions resembling minimal …

This paper reviews current concepts of glomerular immune injury of both inflammatory and
noninflammatory types. In noninflammatory lesions induced by antibody alone or C5b-9, the …

Although glomerular disease remains the most common cause of end-stage renal disease
worldwide, major advances have been made recently in understanding the cellular and …

Immunopathologic studies over the past two decades have demonstrated that rapidly
progressive glomerulonephritis (RPGN) can result from glomerular deposition of anti-GBM …

We investigated whether platelet-derived growth factor (PDGF), or its receptor (PDGF-R),
was upregulated in a rat model of mesangial proliferative glomerulonephritis. A marked …

Proliferation of mesangial cells and expansion of mesangial matrix are common histologic
features of proliferative glomerular disease, a frequent cause of renal failure. Proliferation of …

Progressive renal disease in glomerulonephritis (GN) involves both glomerular and
interstitial processes. In the glomerulus, sclerosis occurs with progressive accumulation of …

Mechanisms of glomerular proteinuria and hematuria. The barrier function of glomerular
capillaries in vivo, which prevents the leakage of plasma proteins and cellular elements …

Platelet-derived growth factor (PDGF) is an important mitogenic factor for various cells. In
order to elucidate the role of PDGF in the development of human glomerulonephritis, we …

An approach for establishing a role for a growth factor in glomerular disease is presented.
Using platelet-derived growth factor (PDGF) as an example, there is strong evidence to …