Pancreatic ductal adenocarcinoma (PDAC) is one of the main aggressive types of cancer,
characterized by late prognosis and drug resistance. Among the main factors sustaining …

Among the different hallmarks of cancer, deregulation of cellular metabolism turned out to be
an essential mechanism in promoting cancer resistance and progression. The pyruvate …

Pyruvate dehydrogenase kinases (PDKs) are serine/threonine kinases, that are directly
involved in altered cancer cell metabolism, resulting in cancer aggressiveness and …

Pharmacologic inhibition of the oncogenic protein kinases using small molecules is a
promising strategy to combat several human malignancies. CDK1 is an example of such a …

Warburg effect, a preference of aerobic glycolysis for energy production even in the
presence of adequate oxygen, is one of the most prominent distinctions of cancer cells from …

Abstract Pyruvate dehydrogenase kinase 3 (PDK3) is a multifunctional enzyme that plays a
central role in the cancer metabolic switch by blocking pyruvate catabolism in the TCA cycle …

In this study, we report on pyrazin-2 (1 H)-ones as lead for the development of potent
adenosine triphosphate (ATP) competitive protein kinase inhibitors with implications as anti …

An efficient synthesis of substituted pyrido [2, 3-d] pyrimidines was carried out and evaluated
for in vitro anticancer activity against five cancer cell lines, namely hepatic cancer (HepG-2) …

Human health in the current medical era is facing numerous challenges, especially cancer.
So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small …

Proliferating cancer cells are characterized by the Warburg effect, a metabolic alteration in
which ATP is generated from cytoplasmic glycolysis instead of oxidative phosphorylation …