Renal fibrosis is the culmination of processes driven by signaling pathways involving
transforming growth factor-β family of cytokines, connective-tissue growth factor, nuclear …

The Wnt/β-catenin signaling pathway plays important roles in embryonic development and
tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Fibrosis of epithelial parenchymal organs and end-stage organ failure, the final common
pathway of many progressive chronic diseases including chronic kidney disease, continue …

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …

Renal fibrosis is a failed wound-healing process of the kidney tissue after chronic, sustained
injury, which is a common pathway and pathological marker of virtually every type of chronic …

Kidney fibrosis is the final common pathway of virtually all chronic kidney diseases (CKDs)
and is therefore considered to be a promising therapeutic target for these conditions …

Renal fibrosis is an important component of chronic kidney disease, an incurable pathology
with increasing prevalence worldwide. With a lack of available therapeutic options, end …

Renal fibrosis is a common consequence and often a central feature of all the progressive
renal diseases that lead to end-stage renal failure. In comparison to wound healing, during …

Introduction The current therapeutic armamentarium to prevent chronic kidney disease
(CKD) progression is limited to the control of blood pressure and in diabetic patients, the …