Natural products of herbal origin are prodigious to display diverse pharmacological
activities. In the present study, five guaiane-type sesquiterpene dimers, xylopidimers A− E (1 …

Six kuwanon derivatives (A/B/C/E/H/J) extracted from the roots of Morus alba L. were
evaluated to determine their cyclooxygenase (COX)-1 and 2 inhibitory effects …

Plant resins are rich in bioactive compounds with high medicinal values. However, the
chemistry and anti-inflammatory activity of the resins produced by trees of the genus …

Inflammation is a natural protective response toward various simulators, including tissue
damage or pathogens. The cyclooxygenase-2 (COX-2) is a very important protein in …

Abstract Cyclooxygenase-2 (COX-2) enzyme inhibitors have not eliminated the necessity for
developed drugs not only in the nonsteroidal anti-inflammatory drug (NSAIDs) area, but also …

Non-steroidal anti-inflammatory drugs (NSAID) targeting cyclooxygenase-2 are clinically
effective. However, they lack anti-thrombotic activity resulting in incidences of adverse …

Background: Natural products from herbs are abundant and display powerful anti-cancer
activities. Objectives: In the current study, B-Raf kinase protein (PDB: 3OG7), a potent target …

Abstract Cyclooxygenase-2 (COX-2) is the key enzyme responsible for the conversion of
arachidonic acid to prostaglandins that display pro-inflammatory properties and thus, it is a …

Abstract Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., popularly known as 'Siberian
ginseng', is an important medicinal plant. Pharmacologically active compounds of this plant …

Drug discovery for a vigorous and feasible lead candidate is a challenging scientific mission
as it requires expertise, experience, and huge investment. Natural products and their …