CD44 is a cytotoxic triggering molecule on activated, but not fresh natural killer (NK) cells. In
the current study, metabolic pathways used in CD44-directed lysis (CD44DL) were …

Natural killer (NK) cells can express high levels of CD44, and signaling through CD44 has
been shown to enhance NK cell cytotoxic activity. However, little is known about the factors …

We recently showed evidence of CD44‐mediated enhancement of natural killer (NK) cell
cytotoxic activity and induction of intracellular Ca2+ flux. In this study, we evaluated whether …

Receptors used by natural killer (NK) cells to mediate natural cytotoxicity are poorly defined,
although it is now clear that a number of adhesion molecules can serve this function. CD38 …

Natural killer (NK) cell activation is the result of a balance between positive and negative
signals triggered by specific membrane receptors. We report here the activation of NK cells …

Previous studies have shown that target cells that bind to CD44 adhesion molecules on
cloned cytotoxic T cells are lysed by the CTL. To determine whether CD44 is also a cytotoxic …

T cells upon activation are known to up‐regulate CD44 expression. However, the precise
function of CD44 on activated T cells is not clear. In this report, we demonstrate that …

CD44, a major hyaluronate receptor, is involved in a variety of lymphocyte functions
including lympho-hemopoiesis, adhesion to high endothelial venules or the extracellular …

IL-2-activated NK cells exhibit cytotoxic activity against a wide variety of tumor cells in a non-
MHC-restricted fashion and in the absence of prior sensitization. The molecular mechanisms …

CD38, a surface glycoprotein of unrestricted lineage, is an ectoenzyme (adenosine
diphosphate [ADP] ribosyl cyclase/cyclic ADP-ribose hydrolase) that regulates cytoplasmic …