T cell-independent type I antibody response against B cell epitopes expressed repetitively on recombinant virus particles
T Fehr, D Skrastina, P Pumpens… - Proceedings of the …, 1998 - National Acad Sciences
Recombinant viral or virus-like particles offer new tools for vaccine development. This study
investigated hepatitis B core antigen (HBcAg) capsids and RNA phage Qβ coats as carriers …
investigated hepatitis B core antigen (HBcAg) capsids and RNA phage Qβ coats as carriers …
Core particles of hepatitis B virus as carrier for foreign epitopes
R Ulrich, M Nassal, H Meisel, DH Krüger - Advances in virus research, 1998 - Elsevier
Publisher Summary More recently, recombinant DNA techniques have been used to insert
foreign epitopes into proteins with inherent multimerization capacity, such as particle …
foreign epitopes into proteins with inherent multimerization capacity, such as particle …
The position of heterologous epitopes inserted in hepatitis B virus core particles determines their immunogenicity
F Schödel, AM Moriarty, DL Peterson, JA Zheng… - Journal of …, 1992 - Am Soc Microbiol
The nucleocapsid (HBcAg) of the hepatitis B virus (HBV) has been suggested as a carrier
moiety for vaccine purposes. We investigated the influence of the position of the inserted …
moiety for vaccine purposes. We investigated the influence of the position of the inserted …
The hepatitis nucleocapsid as a vaccine carrier moiety.
DR Milich, DL Peterson, J Zheng… - Annals of the New …, 1995 - europepmc.org
The" carrier effect," defined as the provision of T cell recognition sites physically linked to B
cell epitopes in order to provide Th cell function for antibody synthesis, is well known …
cell epitopes in order to provide Th cell function for antibody synthesis, is well known …
Hepatitis B synthetic immunogen comprised of nucleocapsid T-cell sites and an envelope B-cell epitope.
DR Milich, JL Hughes, A McLachlan… - Proceedings of the …, 1988 - National Acad Sciences
Previous studies located T-cell recognition of the nucleocapsid of the hepatitis B virus
(HBcAg) to residues 120-140 in mice bearing the H-2s or H-2b haplotypes. Herein, we …
(HBcAg) to residues 120-140 in mice bearing the H-2s or H-2b haplotypes. Herein, we …
Immunizations with chimeric hepatitis B virus-like particles to induce potential anti-hepatitis C virus neutralizing antibodies
PTK Vietheer, I Boo, HE Drummer… - Antiviral therapy, 2007 - journals.sagepub.com
Background Virus-like particles (VLPs) are highly immunogenic and proven to induce
protective immunity. The small surface antigen (HBsAg-S) of hepatitis B virus (HBV) self …
protective immunity. The small surface antigen (HBsAg-S) of hepatitis B virus (HBV) self …
Antigenicity and immunogenicity of novel chimeric hepatitis B surface antigen particles with exposed hepatitis C virus epitopes
HJ Netter, TB Macnaughton, WP Woo, R Tindle… - Journal of …, 2001 - Am Soc Microbiol
The small envelope protein of hepatitis B virus (HBsAg-S) can self-assemble into highly
organized virus like particles (VLPs) and induce an effective immune response. In this study …
organized virus like particles (VLPs) and induce an effective immune response. In this study …
Native display of complete foreign protein domains on the surface of hepatitis B virus capsids
PA Kratz, B Böttcher, M Nassal - Proceedings of the …, 1999 - National Acad Sciences
The nucleocapsid of hepatitis B virus (HBV), or HBcAg, is a highly symmetric structure
formed by multiple dimers of a single core protein that contains potent T helper epitopes in …
formed by multiple dimers of a single core protein that contains potent T helper epitopes in …
[HTML][HTML] A molecular assembly system for presentation of antigens on the surface of HBc virus-like particles
EA Blokhina, VV Kuprianov, LA Stepanova… - Virology, 2013 - Elsevier
Hepatitis B virus-like particles, icosahedral structures formed by multiple core protein dimers,
are promising immune-enhancing vaccine carriers for foreign antigens. Insertions into the …
are promising immune-enhancing vaccine carriers for foreign antigens. Insertions into the …
Virus-like Particles Induce MHC Class I-Restricted T-Cell Responses: Lessons learned from the hepatitis B small surface antigen
R Schirmbeck, W Böhm, J Reimann - Intervirology, 1996 - karger.com
H-2d mice generated a major histocompatibility complex (MHC) class I (Ld)-restricted T-cell
response of defined restriction and epitope specificity to the hepatitis B virus small surface …
response of defined restriction and epitope specificity to the hepatitis B virus small surface …