The Nod-like receptor protein 3 (NLRP3) inflammasome is a multi-protein complex
composed of NLRP3, pro-caspase-1, and apoptosis-associated speck-like protein that …

The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern
recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns …

Objective Reactive oxygen species (ROS) plays a critical role in the regulation of NLRP3
inflammasome activation. However, the ROS-mediated signaling pathways controlling …

Aberrant activation of the NLRP3 inflammasome promotes the pathogenesis of many
inflammatory diseases. The development of the NLRP3 inflammasome inhibitors from …

The NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, a
multiprotein complex, triggers caspase-1 activation and maturation of the proinflammatory …

The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …

The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely
studied inflammasome and has become a hot topic of recent research. As a macromolecular …

NLRP3 inflammasome plays a critical role in the activation of caspase-1 and maturation of IL-
1β. However, the specific cis-and trans-regulatory elements that determine the extent of …

The NLRP3 inflammasome is involved in caspase-1-dependent maturation of IL-1β in many
contexts. A two-signal model has emerged for IL-1β maturation, with LPS providing" signal I" …