Expression and clinical significance of GRHL2 in colorectal cancer

Y Quan, M Xu, P Cui, M Ye, B Zhuang… - Zhonghua Zhong liu za …, 2015 - europepmc.org
Objective The purpose of this study was to detect the expression of GRHL2 in colorectal
cancer (CRC) tissues, and to assess the relationship between GRHL2 expression and …

GRHL3 promotes tumor growth and metastasis via the MEK pathway in colorectal cancer

L Tan, W Qu, D Wu, M Liu, Q Wang, Q Ai… - Analytical Cellular …, 2021 - Wiley Online Library
GRHL3 is a factor associated with a tumor, of which the molecular mechanism remains a
further investigation. We explored the underlying mechanism of tumor‐promoting effect of …

Expression and role of grainyhead-like 2 in gastric cancer

J Xiang, X Fu, W Ran, X Chen, Z Hang, H Mao… - Medical oncology, 2013 - Springer
The aim of this study was to evaluate the expression and role of Grhl2 in gastric cancer.
Immunohistochemistry was performed to explore the expression of Grhl2 in gastric cancer …

Knockdown of GRHL2 inhibited proliferation and induced apoptosis of colorectal cancer by suppressing the PI3K/Akt pathway

F Hu, Z He, C Sun, D Rong - Gene, 2019 - Elsevier
Abstract Grainyhead-like 2 (GRHL2) transcription factor is implicated in many types of
cancers. However, the role of GRHL2 in colorectal cancer (CRC) has not been fully …

Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1

Y Quan, R Jin, A Huang, H Zhao, B Feng… - Cancer biology & …, 2014 - Taylor & Francis
Previous reports have associated GRHL2 with tumor progression. However, the biological
role of GRHL2 in human colorectal cancer (CRC) has not been explored. We examined the …

Clinical implications of GRHL3 protein expression in breast cancer

H Xu, C Liu, Z Zhao, N Gao, G Chen, Y Wang, J Cui - Tumor Biology, 2014 - Springer
The objective of this study was to investigate the expression and significance of the GRHL3
protein in breast cancer diagnosis and prognosis. Overall, 111 patients with histologically …

[HTML][HTML] Grainyhead-like 2 promotes tumor growth and is associated with poor prognosis in colorectal cancer

Y Quan, M Xu, P Cui, M Ye, B Zhuang, Z Min - Journal of Cancer, 2015 - ncbi.nlm.nih.gov
GRHL2 was implicated in regulating cancer development. Our previous study demonstrated
that knockdown GRHL2 in colorectal cancer (CRC) cells inhibited cell proliferation by …

Expression and significance of GRHL2 in esophageal cancer

C Shao, C Ji, X Wang, B Hu - OncoTargets and therapy, 2017 - Taylor & Francis
Esophageal cancer (EC) is one of the most common causes of cancer-related mortality in
the world. Although much effort has been made to improve the 5-year survival rate of …

Knockdown of GRHL3 inhibits activities and induces cell cycle arrest and apoptosis of human colorectal cancer cells

X Wang, F Zhou, H Tao, X Wang, C Zhang, F Su… - Current Medical …, 2017 - Springer
Summary The Grainyhead-like 3 (GRHL3) is involved in epidermal barrier formation, neural
tube closure and wound repair. Previous studies have suggested that GRHL3 has been …

Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma

Y Tanaka, F Kanai, M Tada, R Tateishi, M Sanada… - Journal of …, 2008 - Elsevier
BACKGROUND/AIMS: The aim of this study is to identify genomic changes that might be
implicated in hepatocellular carcinoma (HCC) progression, and evaluate the associations …